The University of Texas Health Science Center at San Antonio, Department of Microbiology & Immunology, 7703 Floyd Curl Drive, MC7758, San Antonio, TX 78229-3900, USA.
Future Microbiol. 2012 Feb;7(2):227-39. doi: 10.2217/fmb.11.160.
Nasopharyngeal colonization provides bacteria with a place of residence, a platform for person-to-person transmission and for many opportunistic pathogens it is a prerequisite event towards the development of invasive disease. Therefore, how host factors within the nasopharynx contribute to, inhibit or otherwise shape biofilm formation, the primary mode of existence for colonizing bacteria, and how biofilm bacteria subvert the acute inflammatory response that facilitates clearance, are important topics for future microbiological research. This review proposes the examination of host components as bridging molecules for bacterial interactions during biofilm formation, altered virulence determinant production and cell wall modification as a mechanism for immunoquiescence, and the role of host factors as signals and co-opted mechanisms for bacterial dissemination, together providing an opportunity for disease.
鼻咽定植为细菌提供了一个居住场所、一个人际传播的平台，对于许多机会性病原体而言，它是发展为侵袭性疾病的先决条件事件。因此，鼻咽内的宿主因素如何促进、抑制或以其他方式影响生物膜的形成（定植细菌的主要生存方式），以及生物膜细菌如何颠覆促进清除的急性炎症反应，是未来微生物学研究的重要课题。本综述提出了将宿主成分作为生物膜形成过程中细菌相互作用、改变毒力决定因素产生和细胞壁修饰的桥接分子进行研究，将免疫静止机制作为宿主因素作为信号和细菌传播的被劫持机制的作用，共同为疾病提供机会。
