评估复方利多卡因乳膏缓解腰椎穿刺相关疼痛的疗效；儿童开放与双盲方案的比较。

Evaluating the efficacy of EMLA in alleviating pain associated with lumbar puncture; comparison of open and double-blinded protocols in children.

作者信息

Kapelushnik Joseph, Koren Gideon, Solh Hassan, Greenberg Mark, DeVeber Levert

机构信息

Division of Hematology-Oncology, Department of Pediatrics, Children's Hospital of Western Ontario, London, Ont.Canada Divisions of Clinical Pharmacology and Hematology-Oncology, Department of Pediatrics, Research Institute, Hospital for Sick Children, Toronto, Ont.Canada.

出版信息

Pain. 1990 Jul;42(1):31-34. doi: 10.1016/0304-3959(90)91088-Z.

DOI:10.1016/0304-3959(90)91088-Z

PMID:2234995

Abstract

Potential benefit of the topical anesthetic EMLA prior to lumbar puncture was studied in children with cancer. Comparison was made between 2 types of study: the first one involved 10 children who were enrolled in a double-blind placebo-controlled study and in the second, 18 children in an open crossover study. Although both studies suggested the favourable effects of EMLA in alleviating pain associated with LP, they illustrated the need to perform such studies in a controlled blinded fashion; the effect in the double-blind study was not apparent in some cases, whereas it was clear cut in all open cases.

摘要

对癌症患儿在腰椎穿刺前使用局部麻醉药EMLA的潜在益处进行了研究。比较了两种类型的研究：第一种研究纳入了10名儿童，他们参与了一项双盲安慰剂对照研究；第二种研究纳入了18名儿童，他们参与了一项开放交叉研究。尽管两项研究均表明EMLA在减轻与腰椎穿刺相关的疼痛方面具有有利作用，但它们表明需要以对照盲法进行此类研究；在双盲研究中，某些情况下效果不明显，而在所有开放病例中效果则很明显。