Hsiao Ya-Chuan, Dzau Jacqueline R, Flemmons Meghan S, Asrani Sanjay, Jones Sarah, Freedman Sharon F
Duke Eye Center, Durham, North Carolina 27710, USA.
J AAPOS. 2012 Feb;16(1):58-60. doi: 10.1016/j.jaapos.2011.10.005.
Although intraocular pressure (IOP) is known to vary with the circadian cycle in nonglaucomatous and glaucomatous eyes of adults, the clinical assessment of IOP often relies on periodic measurements obtained at office visits during daytime hours. Little has been reported on diurnal IOP patterns in healthy children. The purpose of this study was to evaluate diurnal IOP in normal eyes of healthy children with the Icare rebound tonometer and when recorded by a parent at home.
This was a prospective study of IOP in normal eyes of healthy children. Children were recruited from a pediatric eye clinic. A parent was instructed on the use of the Icare rebound tonometer by a study physician and demonstrated proficiency its use in the clinic, at which time a masked IOP reading was also made with Goldmann applanation by a different study clinician. Home IOPs were then obtained and recorded 6 times daily at 2- to 3-hours intervals during 2 consecutive days by a parent.
A total of 22 normal eyes (of 11 children) were included. We found that children without glaucoma demonstrate mean diurnal IOP fluctuation of 4-6 mm Hg, with similar IOP between right and left eyes, fair repeatability between consecutive days, and a tendency for higher early morning and lower late evening IOP.
Healthy children without glaucoma demonstrate some diurnal fluctuation in IOP, comparable with that reported in nonglaucomatous eyes of adults. This information should prove as comparative for assessment of IOP fluctuation in children with known or suspected glaucoma.
虽然已知在成年人的非青光眼和青光眼眼中眼压（IOP）会随昼夜节律周期变化，但眼压的临床评估通常依赖于白天门诊时定期测量的数据。关于健康儿童的昼夜眼压模式报道较少。本研究的目的是使用Icare回弹眼压计评估健康儿童正常眼睛的昼夜眼压，并由家长在家中记录。
这是一项关于健康儿童正常眼睛眼压的前瞻性研究。从儿科眼科诊所招募儿童。研究医生指导家长使用Icare回弹眼压计，并在诊所演示其使用方法，此时另一位研究临床医生也会使用Goldmann压平眼压计进行一次盲法眼压读数。然后由家长在连续两天内每天6次、间隔2至3小时获取并记录家庭眼压数据。
共纳入11名儿童的22只正常眼睛。我们发现，没有青光眼的儿童昼夜眼压平均波动为4至6毫米汞柱，左右眼眼压相似，连续两天之间的重复性良好，且有清晨眼压较高、傍晚眼压较低的趋势。
没有青光眼的健康儿童眼压存在一定的昼夜波动，与成年人非青光眼眼中报道的情况相当。这些信息对于评估已知或疑似青光眼儿童的眼压波动应具有比较价值。
