Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura Giovanni Paolo II, Largo Gemelli 1, 86100, Campobasso, Italy.
Int J Public Health. 2012 Jun;57(3):569-79. doi: 10.1007/s00038-012-0346-0. Epub 2012 Feb 28.
To evaluate the response to pandemic vaccination and seasonal and pandemic vaccine effectiveness (VE) in an Italian adult population, during the 2009-2010 influenza season.
Data were recorded by interviewing 19,275 subjects (≥35 years), randomly recruited from the general population of the Moli-sani project. Events [influenza-like illness (ILI), hospitalization and death], which had occurred between 1 November 2009 and 31 January 2010 were considered. VE was analyzed by multivariable Poisson regression analysis.
Pandemic vaccine coverage was very low (2.4%) in subjects at high-flu risk, aged 35-65 years (N = 8,048); there was no significant preventive effect of vaccine against ILI. Seasonal vaccine coverage was 26.6% in the whole population (63% in elderly and 21.9% in middle-aged subjects at high-flu risk). There was a higher risk to develop ILI in middle-age [VE: -17% (95% CI: -35,-1)] or at high flu-risk [VE: -17% (95% CI: -39, 2)] vaccinated groups.
Coverage of pandemic vaccine was very low in a Southern Italy population, with no protective effect against ILI.
评估意大利成年人群对大流行疫苗接种和季节性及大流行疫苗有效性（VE）的反应，评估时间为 2009-2010 年流感季节。
通过访谈随机招募的来自莫利萨尼项目的普通人群中的 19275 名（年龄≥35 岁）受试者来记录数据。将 2009 年 11 月 1 日至 2010 年 1 月 31 日期间发生的事件（流感样疾病（ILI）、住院和死亡）视为研究事件。通过多变量泊松回归分析来分析 VE。
高风险流感的 35-65 岁人群（N=8048）中，大流行疫苗接种率非常低（2.4%）；疫苗对 ILI 没有明显的预防作用。在整个人群中，季节性疫苗覆盖率为 26.6%（老年人为 63%，高风险流感的中年人群为 21.9%）。在中年人群（VE：-17%（95% CI：-35，-1））或高风险流感人群（VE：-17%（95% CI：-39，2））中，接种疫苗的人群发生 ILI 的风险更高。
意大利南部人群的大流行疫苗接种率非常低，对 ILI 没有保护作用。
