Golay A, Ferrara J M, Felber J P, Schneider H
Department of Internal Medicine, Lausanne University Hospital, Switzerland.
Am J Clin Nutr. 1990 Dec;52(6):1014-9. doi: 10.1093/ajcn/52.6.1014.
The effect of skim milk from cows immunized against a variety of human intestinal bacteria on serum cholesterol concentrations was examined in 11 patients with primary hypercholesterolemia in a 24-wk, randomized, double-blind, placebo-controlled, crossover study. After a 4-wk baseline period, patients were treated for 8 wk either with skim milk from immunized cows (active) or with control skim milk (placebo) followed by an 8-wk period with the treatment order reversed. Eight weeks of active treatment with skim milk from immunized cows reduced serum total cholesterol concentrations by 0.52 +/- 0.59 mmol/L (mean +/- SD; P less than 0.025), or 8%, LDL cholesterol by 0.16 +/- 0.59 mmol/L (NS), or 4%, and the atherogenic index (total cholesterol/HDL cholesterol) by 0.42 +/- 1.85 (P less than 0.05), or 8%, compared with the placebo treatment. Reversal of the favorable development occurred upon cessation of active treatment. We conclude that daily supplementation of a normal diet with skim milk from immunized cows can result in a significant reduction of elevated blood cholesterol concentrations.
在一项为期24周的随机、双盲、安慰剂对照、交叉研究中，对11名原发性高胆固醇血症患者研究了用针对多种人类肠道细菌免疫的奶牛的脱脂牛奶对血清胆固醇浓度的影响。在4周的基线期后，患者接受8周的治疗，要么是用免疫奶牛的脱脂牛奶（活性组），要么是用对照脱脂牛奶（安慰剂组），然后是8周的治疗顺序颠倒的时期。与安慰剂治疗相比，用免疫奶牛的脱脂牛奶进行8周的活性治疗使血清总胆固醇浓度降低了0.52±0.59 mmol/L（均值±标准差；P<0.025），即降低了8%，低密度脂蛋白胆固醇降低了0.16±0.59 mmol/L（无统计学意义），即降低了4%，动脉粥样硬化指数（总胆固醇/高密度脂蛋白胆固醇）降低了0.42±1.85（P<0.05），即降低了8%。停止活性治疗后，这种有利的变化发生了逆转。我们得出结论，在正常饮食中每日补充免疫奶牛的脱脂牛奶可显著降低升高的血液胆固醇浓度。
