Faden H, Rossi T M
Dig Dis Sci. 1985 Feb;30(2):139-42. doi: 10.1007/BF01308200.
The activity of inflammatory bowel disease (IBD) is often difficult to monitor by currently available laboratory tests. The oxidative metabolic activity of Ficoll-Hypaque separated human neutrophils was determined in a luminol-dependent chemiluminescence assay and compared to the white blood cell (WBC) count and the erythrocyte sedimentation rate (ESR) among 13 subjects with inflammatory bowel disease. Clinical disease activity was assessed with a standardized scoring system and judged to be mild in five subjects and absent (remission) in the other eight subjects. The chemiluminescent response of neutrophils was increased among 12 persons compared to that of healthy subjects. In contrast, the WBC count and ESR were abnormal only among two and four individuals, respectively. The widespread abnormality in neutrophil chemiluminescence, even among subjects classified as being in remission, suggests that chemiluminescence determinations may provide a means to monitor longitudinal changes in disease activity.
炎症性肠病（IBD）的活动情况通常难以通过目前可用的实验室检测进行监测。在一项基于鲁米诺的化学发光测定中，对经聚蔗糖-泛影葡胺分离的人类中性粒细胞的氧化代谢活性进行了测定，并将其与13例炎症性肠病患者的白细胞（WBC）计数和红细胞沉降率（ESR）进行了比较。采用标准化评分系统评估临床疾病活动情况，判定5例患者病情为轻度，其余8例患者病情缓解（无疾病活动）。与健康受试者相比，12例患者的中性粒细胞化学发光反应增强。相比之下，WBC计数和ESR分别仅在2例和4例个体中出现异常。即使在被归类为病情缓解的受试者中，中性粒细胞化学发光也普遍存在异常，这表明化学发光测定可能为监测疾病活动的纵向变化提供一种方法。
