Katsuki T, Hinuma Y, Saito T, Yamamoto J, Hirashima Y, Sudoh H, Deguchi M, Motokawa M
Int J Cancer. 1979 Jun 15;23(6):746-50. doi: 10.1002/ijc.2910230603.
EBNA-positive lymphoblast cells were detected in 0.1 to 0.9% of the T-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA-positive colonies in soft agar containing EBV antibodies. The ratio of the colony formers to EBNA-positive cells was higher in blood samples taken early in the disease than in those obtained in later stages of the disease. The present results strongly suggest that EBV-transformed cells are present in the peripheral circulation of IM patients and that such cells can directly give rise to immortalized cell lines in vitro.
在5例传染性单核细胞增多症（IM）患者外周血样本中获得的T细胞耗竭淋巴细胞中，检测到EBNA阳性淋巴母细胞的比例为0.1%至0.9%。5例患者中有4例的相同血液标本含有在含EBV抗体的软琼脂中形成EBNA阳性集落的细胞。疾病早期采集的血样中集落形成细胞与EBNA阳性细胞的比例高于疾病后期采集的血样。目前的结果有力地表明，EBV转化细胞存在于IM患者的外周循环中，并且这些细胞能够在体外直接产生永生化细胞系。
