• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用于无标记生物传感的 CMOS 集成薄膜体声波谐振器。

CMOS-integrated film bulk acoustic resonators for label-free biosensing.

机构信息

Siemens AG Munich, Corporate Technology, Otto-Hahn-Ring 6, 81739 Munich, Germany.

出版信息

Sensors (Basel). 2010;10(5):4180-93. doi: 10.3390/s100504180. Epub 2010 Apr 27.

DOI:10.3390/s100504180
PMID:22399875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3292114/
Abstract

The throughput is an important parameter for label-free biosensors. Acoustic resonators like the quartz crystal microbalance have a low throughput because the number of sensors which can be used at the same time is limited. Here we present an array of 64 CMOS-integrated film bulk acoustic resonators. We compare the performance with surface plasmon resonance and the quartz crystal microbalance and demonstrate the performance of the sensor for multiplexed detection of DNA.

摘要

吞吐量是无标记生物传感器的一个重要参数。石英晶体微天平等声波谐振器的吞吐量较低,因为同时使用的传感器数量有限。在这里,我们展示了一个由 64 个 CMOS 集成薄膜体声波谐振器组成的阵列。我们将其性能与表面等离子体共振和石英晶体微天平进行了比较,并展示了该传感器在多路 DNA 检测中的性能。

相似文献

1
CMOS-integrated film bulk acoustic resonators for label-free biosensing.用于无标记生物传感的 CMOS 集成薄膜体声波谐振器。
Sensors (Basel). 2010;10(5):4180-93. doi: 10.3390/s100504180. Epub 2010 Apr 27.
2
Film bulk acoustic resonators (FBARs) as biosensors: A review.薄膜体声波谐振器(FBAR)作为生物传感器:综述。
Biosens Bioelectron. 2018 Sep 30;116:1-15. doi: 10.1016/j.bios.2018.05.028. Epub 2018 May 18.
3
A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions.2001年至2005年石英晶体微天平生物传感器文献综述:声学物理在生物分子相互作用分析中的应用
J Mol Recognit. 2007 May-Jun;20(3):154-84. doi: 10.1002/jmr.826.
4
Validation of a phase-mass characterization concept and interface for acoustic biosensors.声学生物传感器的相位-质量特征化概念和接口的验证。
Sensors (Basel). 2011;11(5):4702-20. doi: 10.3390/s110504702. Epub 2011 Apr 28.
5
On the applicability of high frequency acoustic shear mode biosensing in view of thickness limitations set by the film resonance.基于薄膜共振所设定的厚度限制探讨高频声学剪切模式生物传感的适用性。
Biosens Bioelectron. 2009 Jul 15;24(11):3387-90. doi: 10.1016/j.bios.2009.04.021. Epub 2009 Apr 23.
6
Biotin-streptavidin binding interactions of dielectric filled silicon bulk acoustic resonators for smart label-free biochemical sensor applications.用于智能无标记生化传感器应用的填充电介质的硅体声波谐振器的生物素-链霉亲和素结合相互作用。
Sensors (Basel). 2014 Mar 7;14(3):4585-98. doi: 10.3390/s140304585.
7
Lateral field excitation (LFE) of thickness shear mode (TSM) acoustic waves in thin film bulk acoustic resonators (FBAR) as a potential biosensor.薄膜体声波谐振器(FBAR)中厚度剪切模式(TSM)声波的横向场激发(LFE)作为一种潜在的生物传感器。
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:4590-3. doi: 10.1109/IEMBS.2006.259241.
8
Detection of DNA hybridisation in a diluted serum matrix by surface plasmon resonance and film bulk acoustic resonators.表面等离子体共振和薄膜体声波谐振器检测稀释血清基质中的 DNA 杂交。
Anal Bioanal Chem. 2011 May;400(5):1387-96. doi: 10.1007/s00216-011-4871-0. Epub 2011 Apr 7.
9
First results on label-free detection of DNA and protein molecules using a novel integrated sensor technology based on gravimetric detection principles.利用基于重量检测原理的新型集成传感器技术对DNA和蛋白质分子进行无标记检测的初步结果。
Biosens Bioelectron. 2004 Jan 15;19(6):615-20. doi: 10.1016/s0956-5663(03)00259-8.
10
Use of torsional resonators to monitor electroactive biofilms.利用扭转谐振器监测电活性生物膜。
Biosens Bioelectron. 2018 Jul 1;110:225-232. doi: 10.1016/j.bios.2018.03.046. Epub 2018 Mar 22.

引用本文的文献

1
Wafer-Scale Graphene Field-Effect Transistor Biosensor Arrays with Monolithic CMOS Readout.具有单片CMOS读出功能的晶圆级石墨烯场效应晶体管生物传感器阵列
ACS Appl Electron Mater. 2023 Aug 24;5(9):4925-4932. doi: 10.1021/acsaelm.3c00706. eCollection 2023 Sep 26.
2
Solidly mounted resonator sensor for biomolecule detections.用于生物分子检测的稳固安装的谐振器传感器。
RSC Adv. 2019 Jul 9;9(37):21323-21328. doi: 10.1039/c9ra01695c. eCollection 2019 Jul 5.
3
Rapid and Easy-to-Use Method for Accurate Characterization of Target Binding and Kinetics of Magnetic Particle Bioconjugates for Biosensing.

本文引用的文献

1
Label-free detection of biomolecular interactions using BioLayer interferometry for kinetic characterization.使用生物层干涉术进行动力学表征的生物分子相互作用的无标记检测。
Comb Chem High Throughput Screen. 2009 Sep;12(8):791-800. doi: 10.2174/138620709789104915.
2
A rapid method for determining dynamic binding capacity of resins for the purification of proteins.一种用于测定树脂对蛋白质纯化的动态结合容量的快速方法。
Protein Expr Purif. 2008 Aug;60(2):147-50. doi: 10.1016/j.pep.2008.04.009. Epub 2008 May 3.
3
On acoustic sensor sensitivity.
用于生物传感的磁性粒子生物缀合物的靶标结合和动力学的快速且易于使用的准确特性分析方法。
Sensors (Basel). 2021 Apr 15;21(8):2802. doi: 10.3390/s21082802.
4
Advances in Sensing Technologies for Monitoring of Bone Health.用于监测骨骼健康的传感技术进展。
Biosensors (Basel). 2020 Apr 21;10(4):42. doi: 10.3390/bios10040042.
5
A Flexible Film Bulk Acoustic Resonator Based on -Phase Polyvinylidene Fluoride Polymer.一种基于β相聚偏二氟乙烯聚合物的柔性薄膜体声波谐振器。
Sensors (Basel). 2020 Feb 29;20(5):1346. doi: 10.3390/s20051346.
6
Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review.基于体声波和表面声波的多分析物检测传感器阵列:综述。
Sensors (Basel). 2019 Dec 6;19(24):5382. doi: 10.3390/s19245382.
7
Shear Mode Bulk Acoustic Resonator Based on Inclined -Axis AlN Film for Monitoring of Human Hemostatic Parameters.基于倾斜轴氮化铝薄膜的剪切模式体声波谐振器用于人体止血参数监测。
Micromachines (Basel). 2018 Sep 30;9(10):501. doi: 10.3390/mi9100501.
8
The High Q Factor Lateral Field⁻Excited Thickness Shear Mode Film Bulk Acoustic Resonator Working in Liquid.工作于液体中的高品质因数横向场激发厚度剪切模式薄膜体声波谐振器。
Micromachines (Basel). 2016 Dec 14;7(12):231. doi: 10.3390/mi7120231.
9
ZnO Film Bulk Acoustic Resonator for the Kinetics Study of Human Blood Coagulation.用于人体血液凝固动力学研究的 ZnO 薄膜体声波谐振器。
Sensors (Basel). 2017 May 3;17(5):1015. doi: 10.3390/s17051015.
10
Gravimetric sensors operating at 1.1 GHz based on inclined c-axis ZnO grown on textured Al electrodes.基于在织构化铝电极上生长的倾斜c轴氧化锌的1.1吉赫兹重量传感器。
Sci Rep. 2017 May 2;7(1):1367. doi: 10.1038/s41598-017-01545-2.
关于声学传感器的灵敏度。
IEEE Trans Ultrason Ferroelectr Freq Control. 1991;38(3):311. doi: 10.1109/58.79617.
4
Formation of irreversibly bound annexin A1 protein domains on POPC/POPS solid supported membranes.在POPC/POPS固体支持膜上形成不可逆结合的膜联蛋白A1蛋白结构域。
Biochim Biophys Acta. 2008 Jul-Aug;1778(7-8):1601-10. doi: 10.1016/j.bbamem.2008.01.003. Epub 2008 Jan 12.
5
Surface acoustic wave sensors in the bioanalytical field: recent trends and challenges.生物分析领域中的表面声波传感器:最新趋势与挑战
Anal Chim Acta. 2007 Nov 12;603(2):119-28. doi: 10.1016/j.aca.2007.09.056. Epub 2007 Oct 4.
6
Lateral field excitation (LFE) of thickness shear mode (TSM) acoustic waves in thin film bulk acoustic resonators (FBAR) as a potential biosensor.薄膜体声波谐振器(FBAR)中厚度剪切模式(TSM)声波的横向场激发(LFE)作为一种潜在的生物传感器。
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:4590-3. doi: 10.1109/IEMBS.2006.259241.
7
Towards integrated and sensitive surface plasmon resonance biosensors: a review of recent progress.迈向集成化与高灵敏度表面等离子体共振生物传感器:近期进展综述
Biosens Bioelectron. 2007 Sep 30;23(2):151-60. doi: 10.1016/j.bios.2007.07.001. Epub 2007 Jul 20.
8
Characteristics of pure-shear mode BAW resonators consisting of (1120) textured ZnO films.由(1120)织构ZnO薄膜组成的纯剪切模式BAW谐振器的特性。
IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Aug;54(8):1680-6. doi: 10.1109/tuffc.2007.439.
9
Shear mode coupling and tilted grain growth of A1N thin films in BAW resonators.BAW谐振器中AlN薄膜的剪切模式耦合与倾斜晶粒生长。
IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jul;53(7):1339-43. doi: 10.1109/tuffc.2006.1665082.
10
Lipoate-based imprinted self-assembled molecular thin films for biosensor applications.用于生物传感器应用的基于硫辛酸的印迹自组装分子薄膜。
Biosens Bioelectron. 2007 Jan 15;22(6):912-9. doi: 10.1016/j.bios.2006.03.014. Epub 2006 Apr 25.