Department of Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.
Int J Tuberc Lung Dis. 2012 May;16(5):687-93. doi: 10.5588/ijtld.11.0226.
The International Study of Asthma and Allergies in Childhood (ISAAC) used standardised methods to examine symptom prevalence of asthma, rhinitis and eczema in adolescents and children between Phases I and III. Centres followed essential rules to ensure comparability of methodology, examined by a centralised data centre.
Centre reports (CRs) were compared for both phases and age groups. Methodological differences were categorised under major deviations (centres excluded), minor deviations (deviations identified in published tables) and very minor deviations (deviations not identified).
There were 112 CRs for adolescents and 70 for children. Six centres for adolescents and four for children had major deviations and were excluded. Minor deviations (35 for adolescents and 20 for children) were identified in the publications. Very minor deviations (92 for adolescents and 51 for children) were not identified. The odds ratios for having any differences in methodology between phases with a change in Principal Investigator were 0.80 (95%CI 0.36-1.81) for adolescents and 0.91 (95%CI 0.32-2.62) for children.
The majority of the centres replicated the ISAAC methodology to a high standard. Careful documentation of methodology using standardised tools with careful checks allows the full potential of studies such as ISAAC to be realised.
国际儿童哮喘和过敏研究（ISAAC）使用标准化方法，在第一阶段和第三阶段检查了青少年和儿童的哮喘、鼻炎和湿疹的症状流行率。各中心遵循基本规则，以确保方法的可比性，并由中央数据中心进行检查。
对两个阶段和年龄组的中心报告（CR）进行了比较。方法学差异分为主要偏差（排除中心）、次要偏差（在已发表的表格中发现的偏差）和非常小的偏差（未发现的偏差）。
有 112 份青少年中心报告和 70 份儿童中心报告。有 6 个青少年中心和 4 个儿童中心有主要偏差，被排除在外。在出版物中发现了 35 个青少年中心和 20 个儿童中心的次要偏差。未发现 92 个青少年中心和 51 个儿童中心的非常小的偏差。在有变更主要研究员的情况下，各阶段方法学有任何差异的比值比（OR）分别为青少年的 0.80（95%置信区间（CI）为 0.36-1.81）和儿童的 0.91（95%CI 为 0.32-2.62）。
大多数中心都高度复制了 ISAAC 方法。使用标准化工具和仔细检查来仔细记录方法学，可以充分发挥 ISAAC 等研究的潜力。
