Department of Radiology, Changzheng Hospital, Affiliated to Second Military Medical University, Shanghai, China.
Influenza Other Respir Viruses. 2012 Nov;6(6):e114-9. doi: 10.1111/j.1750-2659.2012.00368.x. Epub 2012 May 2.
The aim of our study was to describe the presentation and illustrate the imaging features of chest high-resolution computed tomography (HRCT) of patients with novel influenza A (H1N1) virus infection.
Data were collected from 163 hospitalized patients between November 2009 and March 2011, who fulfilled the clinical criteria for H1N1 influenza infection and underwent HRCT examinations within 24 hours of admission.
Abnormal findings were observed in 40.5% of the patients. The patients with positive imaging findings were significantly older than patients with normal HRCT findings (P=0.02). The most common finding was ground-glass opacity (GGO) (n=35). Interlobular septal thickening (n=31) and centrilobular nodules (n=30) were the second most frequent findings. Other common findings were consolidation, reticulation, and linear shadow. The most common imaging finding for lung involvement was GGO with a patchy pattern. Pulmonary involvement of the disease may be extensive and variable, but the total volume of affected lung was mostly <1 lobe.
The baseline HRCT may be valuable and suggestive even for non-severe H1N1 infections. When a severe case or a evolution is suspected, chest CT could be essential both for determining the precise extent of parenchymal damage and for monitoring its evolution.
本研究旨在描述新型甲型 H1N1 流感病毒感染患者的胸部高分辨率 CT（HRCT）表现，并举例说明其影像学特征。
收集了 2009 年 11 月至 2011 年 3 月期间 163 例住院患者的数据，这些患者符合 H1N1 流感感染的临床标准，并在入院后 24 小时内接受了 HRCT 检查。
40.5%的患者存在异常发现。具有阳性影像学发现的患者明显比 HRCT 正常的患者年龄更大（P=0.02）。最常见的发现是磨玻璃影（GGO）（n=35）。小叶间隔增厚（n=31）和小叶中心结节（n=30）是第二常见的发现。其他常见的发现包括实变、网状影和线状影。肺部受累最常见的影像学表现为斑片状 GGO。疾病的肺部受累可能广泛且多变，但受累肺的总体积大多<1 个肺叶。
即使对于非严重的 H1N1 感染，基线 HRCT 也可能具有重要的提示价值。当怀疑为严重病例或进展时，胸部 CT 对于确定实质损伤的精确范围和监测其进展至关重要。
