Shen Wan-Qin, Cheng Ke-Jia, Bao Yang-Yang, Zhou Shui-Hong, Yao Hong-Tian
Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
Head Neck Oncol. 2012 May 2;4:18. doi: 10.1186/1758-3284-4-18.
Ceruminous adenoma of the external auditory canal (EAC) is a rare type of tumour that is diagnosed histologically. However, the clinical behaviour of these tumours remains controversial. Here, we report a case of ceruminous adenoma of the EAC and expression of a hypoxia marker.
A 78-year-old man presented with a 6-month history of recurrent otorrhoea in the right ear. Surgery was performed by the transmeatal approach with total removal of the mass. Histopathology revealed a ceruminous adenoma. Tumour cells were positive for CK, S-100 protein, Glut-1, HIF-1α, PI3K and p-Akt. There was no evidence of recurrence at last follow-up 27 months after the operation.
Ceruminous adenoma of the EAC is a rare tumour. The treatment of choice is wide local excision with clear margins. To our knowledge, this is the first report of Glut-1 expression and the PI3K/Akt pathway in ceruminous adenoma of the EAC.
外耳道耵聍腺瘤是一种经组织学诊断的罕见肿瘤类型。然而，这些肿瘤的临床行为仍存在争议。在此，我们报告一例外耳道耵聍腺瘤病例及一种缺氧标志物的表达情况。
一名78岁男性，有右耳反复流脓6个月的病史。采用经耳道入路手术，完整切除肿物。组织病理学显示为耵聍腺瘤。肿瘤细胞CK、S-100蛋白、Glut-1、HIF-1α、PI3K和p-Akt呈阳性。术后27个月的最后一次随访时无复发迹象。
外耳道耵聍腺瘤是一种罕见肿瘤。首选治疗方法是切缘清晰的广泛局部切除。据我们所知，这是外耳道耵聍腺瘤中Glut-1表达及PI3K/Akt通路的首例报道。
