Department of Ophthalmology, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
Graefes Arch Clin Exp Ophthalmol. 2013 Jan;251(1):27-34. doi: 10.1007/s00417-012-2031-7. Epub 2012 Apr 29.
To evaluate the ability of confocal scanning laser ophthalmoscope (cSLO) in the retromode imaging modality in detecting retinal changes secondary to exudative age-related macular degeneration (AMD).
Seventeen eyes of 13 consecutive patients affected by CNV secondary to AMD were evaluated with optical coherence tomography (OCT) to detect neuroretinal detachment (NRD), pigment epithelial detachment (PED), cystoid macular edema (CME), and epiretinal membranes (ERM). All eyes were examined with a cSLO equipped with infrared retromode (RM) imaging modality. Infrared and fundus autofluorescence images were also obtained (IR and FAF). The intermethod agreement between OCT and cSLO was evaluated considering single cSLO imaging modality separately (IR, FAF, and RM), and all imaging modalities together.
Eight eyes (47 %) had NRD at OCT; intermethod agreement was poor for any single cSLO imaging modality considered separately (k: 0.14, 0.01, and 0.29 for cSLO IR, FAF, and RM, respectively). Four eyes had PED at OCT (24 %); intermethod agreement was mild for cSLO RM, poor for IR and FAF (k: 0.51, 0.16, and 0.00, respectively). CME was present in eight eyes (47 %); intermethod agreement was excellent for cSLO RM, poor for IR and FAF (k: 0.88, 0.38, and 0.26, respectively). ERM was present in three eyes (18 %); intermethod agreement was mild for cSLO IR, poor for FAF, and excellent for RM (k: 0.59, 0.00, and 0.76, respectively).
cSLO RM imaging is a useful and reproducible technique in detecting retinal features associated with CNV, particularly CME.
评估共焦扫描激光检眼镜（cSLO）在Retromode 成像模式下检测渗出性年龄相关性黄斑变性（AMD）继发的视网膜变化的能力。
对 13 例连续患者的 17 只眼，采用光学相干断层扫描（OCT）检测神经视网膜脱离（NRD）、色素上皮脱离（PED）、囊样黄斑水肿（CME）和视网膜前膜（ERM），以评估 CNV。所有眼睛均采用配备红外Retromode（RM）成像模式的 cSLO 进行检查。还获得了红外和眼底自发荧光图像（IR 和 FAF）。分别考虑单个 cSLO 成像模式（IR、FAF 和 RM）以及所有成像模式的 OCT 和 cSLO 之间的方法间一致性。
在 OCT 上，8 只眼（47%）有 NRD；任何单一的 cSLO 成像模式的方法间一致性都很差（k 值分别为 0.14、0.01 和 0.29）。在 OCT 上，4 只眼有 PED（24%）；cSLO RM 的方法间一致性为轻度，IR 和 FAF 的方法间一致性为差（k 值分别为 0.51、0.16 和 0.00）。在 OCT 上，8 只眼（47%）有 CME；cSLO RM 的方法间一致性为极好，IR 和 FAF 的方法间一致性为差（k 值分别为 0.88、0.38 和 0.26）。ERM 在 3 只眼（18%）中存在；cSLO IR 的方法间一致性为轻度，FAF 的方法间一致性为差，RM 的方法间一致性为极好（k 值分别为 0.59、0.00 和 0.76）。
cSLO RM 成像技术是一种有用且可重复的技术，可用于检测与 CNV 相关的视网膜特征，特别是 CME。
