University of California, Los Angeles - Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA 90095-7076, USA.
Brain Behav Immun. 2013 Mar;30 Suppl(Suppl):S58-67. doi: 10.1016/j.bbi.2012.05.002. Epub 2012 May 24.
Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.
超过三分之二的美国 1140 万癌症幸存者有望长期生存，还有许多人将癌症作为一种通过持续治疗控制的慢性病来对待。然而，在治疗过程中常常会出现行为合并症，并长期存在，从而使生存变得复杂并降低生活质量。在这篇综述中，描述了癌症、抑郁和睡眠障碍之间的相互关系，并重点关注了睡眠障碍作为抑郁风险因素的作用。越来越多的证据还将炎症生物学动态的改变与癌症诊断和治疗的这些长期影响联系起来，并讨论了睡眠障碍驱动炎症的假说，炎症和抑郁共同导致了这一假说。更好地了解炎症与行为合并症之间的关联，有可能改进对癌症幸存者中睡眠障碍和抑郁风险的预测，并制定预防和治疗这两种疾病的策略。
