Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Lab Chip. 2012 Jul 21;12(14):2491-7. doi: 10.1039/c2lc21021e. Epub 2012 May 31.
We have developed an acoustic-based tunable patterning technique by which microparticles or cells can be arranged into reconfigurable patterns in microfluidic channels. In our approach, we use pairs of slanted-finger interdigital transducers (SFITs) to generate a tunable standing surface acoustic wave field, which in turn patterns microparticles or cells in one- or two-dimensional arrays inside the microfluidic channels--all without the assistance of fluidic flow. By tuning the frequency of the input signal applied to the SFITs, we have shown that the cell pattern can be controlled with tunability of up to 72%. This acoustic-based tunable patterning technique has the advantages of wide tunability, non-invasiveness, and ease of integration to lab-on-a-chip systems, and shall be valuable in many biological and colloidal studies.
我们开发了一种基于声学的可调图案化技术，通过该技术可以将微粒子或细胞排列成微流控通道中的可重构图案。在我们的方法中，我们使用一对倾斜指状叉指换能器 (SFIT) 来产生可调谐的驻波声场，该声场反过来可以在微流控通道内的一维或二维阵列中对微粒子或细胞进行图案化——所有这些都无需流体流动的辅助。通过调整施加到 SFIT 的输入信号的频率，我们已经表明可以将细胞图案的可控性提高到 72%。这种基于声学的可调图案化技术具有可调谐性广、非侵入性和易于与片上实验室系统集成的优点，在许多生物和胶体研究中都具有重要价值。
