多位点可变数目串联重复分析显示大环内酯类耐药肺炎支原体分离株的多克隆起源。
Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis.
机构信息
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
出版信息
J Clin Microbiol. 2012 Aug;50(8):2793-5. doi: 10.1128/JCM.00678-12. Epub 2012 May 30.
Abstract
There was a high percentage of macrolide resistance in Mycoplasma pneumoniae clinical isolates in China. The genetic relatedness of macrolide-resistant M. pneunomiae strains was investigated using the multilocus variable-number tandem-repeat assay (MLVA). Among 152 M. pneunomiae isolates, the 137 macrolide-resistant strains were clustered into 15 MLVA types, indicating that the high macrolide resistance rate in M. pneumoniae is a result of the dissemination of the multiple resistant clones.
摘要
中国肺炎支原体临床分离株中存在高比例的大环内酯类耐药。采用多位点可变数目串联重复序列分析（MLVA）对大环内酯类耐药肺炎支原体菌株的遗传相关性进行了研究。在 152 株肺炎支原体分离株中，137 株大环内酯类耐药株聚类为 15 种 MLVA 型，表明肺炎支原体大环内酯类耐药率高是多种耐药克隆传播的结果。
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