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本文引用的文献

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Culture-independent multi-locus variable-number tandem-repeat analysis (MLVA) of Mycoplasma pneumoniae.肺炎支原体的无培养依赖性多位点可变数目串联重复分析（MLVA）。
J Microbiol Methods. 2011 Sep;86(3):393-6. doi: 10.1016/j.mimet.2011.06.008. Epub 2011 Jun 17.
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Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China.中国上海儿童分离株肺炎支原体大环内酯类耐药性特征分析
Diagn Microbiol Infect Dis. 2010 Aug;67(4):355-8. doi: 10.1016/j.diagmicrobio.2010.03.004.
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High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China.中国成人和青少年呼吸道感染肺炎支原体分离株中大环内酯类耐药率高。
Clin Infect Dis. 2010 Jul 15;51(2):189-94. doi: 10.1086/653535.
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Multiple-locus variable number tandem repeat analysis of Staphylococcus aureus: comparison with pulsed-field gel electrophoresis and spa-typing.金黄色葡萄球菌多位点可变数目串联重复序列分析：与脉冲场凝胶电泳及spa分型的比较
PLoS One. 2009;4(4):e5082. doi: 10.1371/journal.pone.0005082. Epub 2009 Apr 3.
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Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.中国肺炎支原体临床分离株大环内酯类耐药的分子机制
Antimicrob Agents Chemother. 2009 May;53(5):2158-9. doi: 10.1128/AAC.01563-08. Epub 2009 Mar 9.
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Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China.中国上海肺炎支原体分离株的抗菌药敏性及大环内酯类耐药菌株的分子分析
Antimicrob Agents Chemother. 2009 May;53(5):2160-2. doi: 10.1128/AAC.01684-08. Epub 2009 Mar 9.
7
Development of multiple-locus variable-number tandem-repeat analysis for molecular typing of Mycoplasma pneumoniae.用于肺炎支原体分子分型的多位点可变数目串联重复序列分析的开发
J Clin Microbiol. 2009 Apr;47(4):914-23. doi: 10.1128/JCM.01935-08. Epub 2009 Feb 9.
8
Multiple-locus variable-number tandem repeat analysis of Neisseria meningitidis yields groupings similar to those obtained by multilocus sequence typing.脑膜炎奈瑟菌多位点可变数目串联重复序列分析产生的分组与多位点序列分型所获得的分组相似。
J Clin Microbiol. 2006 Apr;44(4):1509-18. doi: 10.1128/JCM.44.4.1509-1518.2006.
9
Increase in genetic diversity of Haemophilus influenzae serotype b (Hib) strains after introduction of Hib vaccination in The Netherlands.荷兰引入b型流感嗜血杆菌（Hib）疫苗后，Hib菌株的遗传多样性增加。
J Clin Microbiol. 2005 Jun;43(6):2741-9. doi: 10.1128/JCM.43.6.2741-2749.2005.
10
Mycoplasma pneumoniae and its role as a human pathogen.肺炎支原体及其作为人类病原体的作用。
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多位点可变数目串联重复分析显示大环内酯类耐药肺炎支原体分离株的多克隆起源。

Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis.

机构信息

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

出版信息

J Clin Microbiol. 2012 Aug;50(8):2793-5. doi: 10.1128/JCM.00678-12. Epub 2012 May 30.

DOI:10.1128/JCM.00678-12
PMID:22649013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3421490/
Abstract

There was a high percentage of macrolide resistance in Mycoplasma pneumoniae clinical isolates in China. The genetic relatedness of macrolide-resistant M. pneunomiae strains was investigated using the multilocus variable-number tandem-repeat assay (MLVA). Among 152 M. pneunomiae isolates, the 137 macrolide-resistant strains were clustered into 15 MLVA types, indicating that the high macrolide resistance rate in M. pneumoniae is a result of the dissemination of the multiple resistant clones.

摘要

中国肺炎支原体临床分离株中存在高比例的大环内酯类耐药。采用多位点可变数目串联重复序列分析（MLVA）对大环内酯类耐药肺炎支原体菌株的遗传相关性进行了研究。在 152 株肺炎支原体分离株中，137 株大环内酯类耐药株聚类为 15 种 MLVA 型，表明肺炎支原体大环内酯类耐药率高是多种耐药克隆传播的结果。