Tantawichien Terapong
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Paediatr Int Child Health. 2012 May;32 Suppl 1(s1):22-7. doi: 10.1179/2046904712Z.00000000049.
Dengue fever (DF) is endemic in tropical and subtropical zones and the prevalence is increasing across South-east Asia, Africa, the Western Pacific and the Americas. In recent years, the spread of unplanned urbanisation, with associated substandard housing, overcrowding and deterioration in water, sewage and waste management systems, has created ideal conditions for increased transmission of the dengue virus in tropical urban centres. While dengue infection has traditionally been considered a paediatric disease, the age distribution of dengue has been rising and more cases have been observed in adolescents and adults. Furthermore, the development of tourism in the tropics has led to an increase in the number of tourists who become infected, most of whom are adults. Symptoms and risk factors for dengue haemorrhagic fever (DHF) and severe dengue differ between children and adults, with co-morbidities and incidence in more elderly patients associated with greater risk of mortality. Treatment options for DF and DHF in adults, as for children, centre round fluid replacement (either orally or intravenously, depending on severity) and antipyretics. Further data are needed on the optimal treatment of adult patients.
登革热在热带和亚热带地区呈地方性流行,且在东南亚、非洲、西太平洋和美洲的发病率正在上升。近年来,无规划的城市化进程不断蔓延,随之而来的是住房条件不达标准、过度拥挤以及水、污水和废物管理系统恶化,为登革热病毒在热带城市中心的传播创造了理想条件。虽然登革热感染传统上被视为一种儿科疾病,但登革热的发病年龄分布一直在上升,青少年和成年人中观察到的病例增多。此外,热带地区旅游业的发展导致感染的游客数量增加,其中大多数是成年人。登革出血热(DHF)和重症登革热的症状及危险因素在儿童和成年人中有所不同,合并症以及老年患者中的发病率与更高的死亡风险相关。与儿童一样,成人登革热和登革出血热的治疗方法主要围绕液体补充(根据严重程度口服或静脉注射)和解热药。关于成年患者的最佳治疗方法还需要进一步的数据。