Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Med Microbiol Immunol. 2013 Feb;202(1):87-94. doi: 10.1007/s00430-012-0251-4. Epub 2012 Jun 10.
Location- and age-specific prevalence of antibodies against 2009 pandemic influenza A (H1N1) virus were determined in sera of blood donors collected during winter 2010/2011 in Germany. Prevalence of antibodies at protective titres (HI ≥1:40) varied significantly between cities (24.13-83.67 %) throughout all age groups. However, high level antibodies (HI >1:80) were most prevalent among young individuals (18-29 and 30-39 years). Overall, this study demonstrates that older people (50-59 and 60-70 years) are no longer more likely to present protective antibody titres against 2009 pandemic influenza A (H1N1) virus than younger individuals. Furthermore, our data show a highly variable immunity among the German population in different major cities almost 2 years after the detection of first cases in Germany.
在德国 2010/2011 年冬季采集的献血者血清中，确定了针对 2009 年甲型 H1N1 流感病毒的抗体在地理位置和年龄上的流行情况。在所有年龄组中，保护性抗体（HI ≥1：40）的流行率在不同城市之间存在显著差异（24.13-83.67%）。然而，高滴度抗体（HI>1：80）在年轻人（18-29 岁和 30-39 岁）中最为常见。总体而言，这项研究表明，老年人（50-59 岁和 60-70 岁）与年轻人相比，针对 2009 年甲型 H1N1 流感病毒的保护性抗体滴度不再更高。此外，我们的数据显示，在德国首次发现病例近 2 年后，德国不同主要城市的人群中存在高度可变的免疫性。
