锌、维生素 A 和维生素 C 状况与墨西哥女性瘦素浓度和肥胖有关：一项横断面研究的结果。
Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study.
机构信息
School of Natural Sciences, Universidad Autónoma de Querétaro, Av, De la Ciencia S/N, Juriquilla, Querétaro, 76230, Mexico.
出版信息
Nutr Metab (Lond). 2012 Jun 15;9(1):59. doi: 10.1186/1743-7075-9-59.
BACKGROUND
The prevalence of obesity among Mexican women is high and it could be related to micronutrient status. We evaluated in a cross-sectional study the associations of zinc and vitamins A, C and E concentrations with BMI, central adiposity, body fat and leptin concentration.
METHODS
Women aged 37 ± 7.5 years (n = 580) from 6 rural communities in Mexico were evaluated. Anthropometric measurements included weight, height, waist and hip circumference. A fasting blood sample was taken for the analysis of glucose, lipid profile, leptin, zinc, and vitamins A, C and E. Body composition was determined by DEXA (Hologic Mod Explorer).
RESULTS
The prevalence of overweight and obesity was 36% (BMI > 25 Kg/m2) and 44% (BMI > 30 Kg/m2), respectively. Prevalence of zinc and vitamins C and E deficiencies were similar in obese, overweight and normal weight women. No vitamin A deficiency was found. Vitamin C was negatively associated with BMI, waist-to-height ratio, and leptin concentrations (p < 0.05). Vitamin A was positively associated with leptin (p < 0.05). When stratifying by BMI, % body fat and waist circumference, high leptin concentrations were associated with lower zinc and lower vitamin C concentrations in women with obesity (p < 0.05) and higher vitamin A concentrations in women without obesity (p < 0.01). Vitamin E status was not associated with any markers of obesity.
CONCLUSION
Zinc and vitamins A and C are associated with obesity, adiposity and leptin concentration in women from rural Mexico, and may play an important role in fat deposition. The causality of these associations needs to be confirmed.
背景
墨西哥女性肥胖的患病率很高，这可能与微量营养素状况有关。我们在一项横断面研究中评估了锌和维生素 A、C、E 浓度与 BMI、中心性肥胖、体脂肪和瘦素浓度的关系。
方法
评估了来自墨西哥 6 个农村社区、年龄 37±7.5 岁的 580 名女性。人体测量学测量包括体重、身高、腰围和臀围。采集空腹血样用于分析血糖、血脂谱、瘦素、锌和维生素 A、C、E。使用 DEXA（Hologic Mod Explorer）确定身体成分。
结果
超重和肥胖的患病率分别为 36%（BMI＞25kg/m2）和 44%（BMI＞30kg/m2）。肥胖、超重和正常体重女性的锌和维生素 C 和 E 缺乏的患病率相似。未发现维生素 A 缺乏。维生素 C 与 BMI、腰高比和瘦素浓度呈负相关（p＜0.05）。维生素 A 与瘦素呈正相关（p＜0.05）。当按 BMI、体脂肪百分比和腰围分层时，肥胖女性中高瘦素浓度与较低的锌和较低的维生素 C 浓度相关（p＜0.05），而非肥胖女性中较高的维生素 A 浓度相关（p＜0.01）。维生素 E 状态与肥胖的任何标志物均无关。
结论
锌和维生素 A、C 与墨西哥农村妇女的肥胖、肥胖和瘦素浓度有关，可能在脂肪沉积中发挥重要作用。这些关联的因果关系需要进一步证实。
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