Clark Michelle P, Qayed Emad S, Kooby David A, Maithel Shishir K, Willingham Field F
Division of Digestive Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Minim Invasive Surg. 2012;2012:189296. doi: 10.1155/2012/189296. Epub 2012 Jun 6.
Natural orifice translumenal endoscopic surgery (NOTES) had its origins in numerous small animal studies primarily examining safety and feasibility. In human trials, safety and feasibility remain at the forefront; however, additional logistic, practical, and regulatory requirements must be addressed. The purpose of this paper is to evaluate and summarize published studies to date of NOTES in humans. The literature review was performed using PUBMED and MEDLINE databases. Articles published in human populations between 2007 and 2011 were evaluated. A review of this time period resulted in 48 studies describing procedures in 916 patients. Transcolonic and transvesicular procedures were excluded. The most common procedure was cholecystectomy (682, 75%). The most common approach was transvaginal (721, 79%). 424 procedures (46%) were pure NOTES and 491 (54%) were hybrid NOTES cases. 127 (14%) were performed in the United States of America and 789 (86%) were performed internationally. Since 2007, there has been major development in NOTES in human populations. A preponderance of published NOTES procedures were performed internationally. With further development, NOTES may make less invasive surgery available to a larger human population.
经自然腔道内镜手术（NOTES）起源于众多主要研究安全性和可行性的小动物研究。在人体试验中，安全性和可行性仍然是首要关注点；然而，还必须解决其他后勤、实际操作和监管方面的要求。本文的目的是评估和总结迄今为止已发表的关于人体NOTES的研究。文献综述使用了PUBMED和MEDLINE数据库。对2007年至2011年间发表的涉及人类的文章进行了评估。对这一时期的回顾产生了48项研究，描述了916例患者的手术过程。经结肠和经膀胱手术被排除在外。最常见的手术是胆囊切除术（682例，75%）。最常见的入路是经阴道（721例，79%）。424例手术（46%）为单纯NOTES，491例（54%）为混合NOTES病例。127例（14%）在美国进行，789例（86%）在国际上进行。自2007年以来，人体NOTES有了重大发展。已发表的NOTES手术大多在国际上进行。随着进一步发展，NOTES可能会使更多人能够接受微创手术。
