Department of Neurosurgery, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.
Neurosurg Clin N Am. 2012 Jul;23(3):439-49. doi: 10.1016/j.nec.2012.04.006. Epub 2012 Jun 14.
Glioblastoma remains one of the most difficult cancers to treat and represents the most common primary malignancy of the brain. Although conventional treatments have found modest success in reducing the initial tumor burden, infiltrating cancer cells beyond the main mass are responsible for tumor recurrence and ultimate patient demise. Targeting residual infiltrating cancer cells requires the development of new treatment strategies. The emerging field of cancer nanotechnology holds promise in the use of multifunctional nanoparticles for imaging and targeted therapy of glioblastoma. This article examines the current state of nanotechnology in the treatment of glioblastoma and directions of further study.
胶质母细胞瘤仍然是最难治疗的癌症之一，也是大脑最常见的原发性恶性肿瘤。尽管传统治疗方法在减轻初始肿瘤负担方面取得了一定的成功，但浸润性肿瘤细胞超出主肿瘤范围是肿瘤复发和患者最终死亡的原因。针对残留浸润性肿瘤细胞需要开发新的治疗策略。癌症纳米技术这一新兴领域有望利用多功能纳米粒子对胶质母细胞瘤进行成像和靶向治疗。本文探讨了纳米技术在胶质母细胞瘤治疗中的现状和进一步研究的方向。
