Saunders Travis J, Larouche Richard, Colley Rachel C, Tremblay Mark S
Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada K1H 8L1.
J Nutr Metab. 2012;2012:712435. doi: 10.1155/2012/712435. Epub 2012 Jun 17.
North Americans spend half their waking hours engaging in sedentary behaviour. Although several recent interventions suggest that short bouts of uninterrupted sedentary behaviour may result in acute increases in cardiometabolic risk, this literature has not been reviewed systematically. This study performed a systematic review of the impact of uninterrupted sedentary behaviour lasting ≤7 days on markers of cardiometabolic risk (insulin sensitivity, glucose tolerance, and fasting insulin, glucose, and lipid levels) in humans. Interventions were identified through systematic searches of Medline and Embase and screened by 2 independent reviewers. A total of 25 interventions were identified that examined the impact of imposed sedentary behaviour on biomarkers of interest. The majority of these studies focused on healthy young men, with very little identified research on females or other age groups. We found consistent, moderate quality evidence that uninterrupted sedentary behaviour ≤7 days results in moderate and deleterious changes in insulin sensitivity, glucose tolerance, and plasma triglyceride levels. In contrast, there is inconsistent, very low-quality evidence linking uninterrupted sedentary behaviour with changes in insulin, glucose, and HDL- and LDL-cholesterol levels. These findings suggest that uninterrupted bouts of sedentary behaviour should be avoided in order to prevent or attenuate transient increases in metabolic risk.
北美人清醒时间的一半都用于久坐行为。尽管最近的几项干预措施表明，短时间不间断的久坐行为可能会导致心脏代谢风险急剧增加，但尚未对该文献进行系统综述。本研究对持续≤7天的不间断久坐行为对人体心脏代谢风险标志物（胰岛素敏感性、葡萄糖耐量以及空腹胰岛素、葡萄糖和血脂水平）的影响进行了系统综述。通过对Medline和Embase进行系统检索来确定干预措施，并由两名独立评审员进行筛选。共确定了25项研究干预措施，这些措施研究了强制久坐行为对相关生物标志物的影响。这些研究大多聚焦于健康的年轻男性，针对女性或其他年龄组的研究很少。我们发现了质量中等且一致的证据，表明持续≤7天的不间断久坐行为会导致胰岛素敏感性、葡萄糖耐量和血浆甘油三酯水平出现中度有害变化。相比之下，关于不间断久坐行为与胰岛素、葡萄糖以及高密度脂蛋白和低密度脂蛋白胆固醇水平变化之间的联系，证据不一致且质量极低。这些发现表明，应避免不间断的久坐行为，以预防或减轻代谢风险的短暂增加。
