Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan.
Evid Based Complement Alternat Med. 2012;2012:735481. doi: 10.1155/2012/735481. Epub 2012 Jul 15.
Aging is highly correlated with the progressive loss of physiological function, including cognitive behavior and reproductive capacity, as well as an increased susceptibility to diseases; therefore, slowing age-related degeneration could greatly contribute to human health. Cynomorium songaricum Rupr. (CS) is traditionally used to improve sexual function and treat kidney dysfunction in traditional Chinese medicine, although little is known about whether CS has effects on longevity. Here, we show that CS supplementation in the diet extends both the mean and maximum lifespan of adult female flies. The increase in lifespan with CS was correlated with higher resistance to oxidative stress and starvation and lower lipid hydroperoxides (LPO) levels. Additionally, the lifespan extension was accompanied by beneficial effects, such as improved mating readiness, increased fecundity, and suppression of age-related learning impairment in aged flies. These findings demonstrate the important antiaging effects of CS and indicate the potential applicability of dietary intervention with CS to enhance health and prevent multiple age-related diseases.
衰老是与生理功能的逐渐丧失密切相关的，包括认知行为和生殖能力，以及对疾病的易感性增加；因此，减缓与年龄相关的退化可能对人类健康有很大的贡献。肉苁蓉（CS）在传统中医中被用于改善性功能和治疗肾功能障碍，尽管人们对 CS 是否对长寿有影响知之甚少。在这里，我们表明 CS 补充饮食可以延长成年雌性果蝇的平均寿命和最大寿命。CS 增加寿命与更高的抗氧化应激和饥饿抗性以及更低的脂质过氧化物 (LPO) 水平相关。此外，寿命的延长伴随着有益的效果，例如提高交配准备、增加生育能力和抑制老年果蝇的年龄相关学习障碍。这些发现证明了 CS 的重要抗衰老作用，并表明通过饮食干预 CS 来增强健康和预防多种与年龄相关的疾病具有潜在的适用性。
