School of Bio Sciences and Technology, VIT University, Vellore, 632 014, Tamil Nadu, India.
Inflammation. 2013 Feb;36(1):169-76. doi: 10.1007/s10753-012-9532-8.
In this study, p-coumaric acid was evaluated for its immunomodulatory and anti-inflammatory properties in vivo. The immunomodulatory effect of p-coumaric acid (100 mg/kg body weight) was assessed by evaluating its effect on cell-mediated immune responses (delayed type hypersensitivity reaction), serum immunoglobulin levels, and macrophage phagocytic index in rats. The anti-inflammatory effects of p-coumaric acid (100 mg/kg body weight) were investigated by examining its effect on expression of tumor necrosis factor (TNF-α) in synovial tissue by immunofluorescence confocal microscopy and circulating immune complexes in serum of adjuvant-induced arthritic rats. The increased cell-mediated immune responses and macrophage phagocytic index observed in control rats were significantly reduced (p < 0.05) upon treatment with p-coumaric acid implying its immunosuppressive property, whereas serum immunoglobulin levels were found to be increased in p-coumaric acid treated control rats. p-coumaric acid also showed significant (p < 0.05) anti-inflammatory effects in adjuvant-induced arthritic rats by effecting a decrease in the expression of inflammatory mediator TNF-α and circulating immune complexes. Indomethacin was used as a reference drug for anti-inflammatory studies. Thus, our results show that p-coumaric acid could be considered a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis.
在这项研究中，评估了对香豆酸的体内免疫调节和抗炎特性。通过评估对香豆酸（100mg/kg 体重）对细胞介导的免疫反应（迟发型超敏反应）、血清免疫球蛋白水平和大鼠巨噬细胞吞噬指数的影响，评估了对香豆酸的免疫调节作用。通过免疫荧光共聚焦显微镜检查对香豆酸（100mg/kg 体重）对滑膜组织中肿瘤坏死因子（TNF-α）表达的影响以及对佐剂诱导关节炎大鼠血清循环免疫复合物的影响，研究了对香豆酸的抗炎作用。与对照组相比，用对香豆酸治疗后，观察到的细胞介导的免疫反应和巨噬细胞吞噬指数明显降低（p<0.05），表明其具有免疫抑制特性，而血清免疫球蛋白水平在接受对香豆酸治疗的对照组大鼠中升高。对香豆酸还通过降低炎症介质 TNF-α和循环免疫复合物的表达，对佐剂诱导的关节炎大鼠表现出显著的抗炎作用（p<0.05）。吲哚美辛被用作抗炎研究的参考药物。因此，我们的结果表明，对香豆酸可以被认为是治疗类风湿性关节炎等自身免疫性炎症疾病的潜在免疫抑制剂。
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