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氢化可的松对单纯疱疹病毒体外持续性感染的调节作用

Regulation of persistent infection with herpes simplex virus in vitro by hydrocortisone.

作者信息

Nishiyama Y, Rapp F

出版信息

J Virol. 1979 Sep;31(3):841-4. doi: 10.1128/JVI.31.3.841-844.1979.

Abstract

About 1% of Raji cells showed sensitivity to herpes simplex virus type 2 (HSV-2) infection when tested by infectious center assays or immunofluorescence tests, and the percentage did not change during cell passage. The addition of hydrocortisone to Raji cells persistently infected with HSV-2 caused a marked increase in virus production and in the number of HSV-producing cells. In the case of HSV-1, it was shown that the addition of hydrocortisone was required to maintain persistent infection. These observations suggest that control of replication of HSV-1 and HSV-2 in these cells is regulated by different mechanisms.

摘要

通过感染中心试验或免疫荧光试验检测时,约1%的Raji细胞对2型单纯疱疹病毒(HSV - 2)感染敏感,且该百分比在细胞传代过程中未发生变化。向持续感染HSV - 2的Raji细胞中添加氢化可的松会导致病毒产量和产生HSV的细胞数量显著增加。对于HSV - 1,结果表明需要添加氢化可的松来维持持续感染。这些观察结果表明,HSV - 1和HSV - 2在这些细胞中的复制控制受不同机制调节。

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