Mohamed Aezeden, Xing Malcolm Mengqiu
Nano-Medicine and Tissue Engineering Lab, Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba and Manitoba Institute of Child Health Winnipeg, Manitoba, Canada.
Int J Burns Trauma. 2012;2(1):29-41. Epub 2012 Mar 15.
A recent literature review of the field shows that tissue-engineered skin has been in clinical use for the last several decades and that, over this time the technology has advanced rapidly. Despite this progress no synthetic skin yet produced has completely replicated normal, healthy skin. Therefore, researchers must continue to develop materials that successfully overcome the problems with current skin tissue substitutes. This paper is a comprehensive review of the prospects for nanotechnology and nanomaterials to close this gap by mimicking surface properties for reconstruction of a variety of skin tissues. In addition, a number of commercially available products that regenerate different layers of the burn-damaged or chronically wounded skin are reviewed.
该领域最近的一篇文献综述表明，组织工程皮肤在过去几十年中一直在临床使用，并且在此期间该技术发展迅速。尽管取得了这一进展，但目前生产的合成皮肤仍未完全复制正常、健康的皮肤。因此，研究人员必须继续开发能够成功克服当前皮肤组织替代品问题的材料。本文全面综述了纳米技术和纳米材料通过模拟表面特性来重建各种皮肤组织以弥合这一差距的前景。此外，还对一些可用于再生烧伤或慢性伤口不同皮肤层的商业产品进行了综述。
