Department of Radiation Oncology, Technische Universität München, Klinikum rechts der Isar, München, Germany.
J Biophotonics. 2012 Nov;5(11-12):903-11. doi: 10.1002/jbio.201200078. Epub 2012 Aug 29.
Laser-accelerated particles are a promising option for radiation therapy of cancer by potentially combining a compact, cost-efficient treatment unit with the physical advantages of charged particle beams. To design such a treatment unit we consider different dose delivery schemes and analyze the necessary devices in the required particle beam line for each case. Furthermore, we point out that laser-driven treatment units may be ideal tools for motion adaptation during radiotherapy. Reasons for this are the potential of a flexible gantry and the time structure of the beam with high particle numbers in ultrashort bunches. One challenge that needs to be addressed is the secondary radiation produced in several beam line elements.
激光加速粒子是癌症放射治疗的一种很有前途的选择，它有可能将一个紧凑、高效成本的治疗单元与带电粒子束的物理优势结合起来。为了设计这样一个治疗单元，我们考虑了不同的剂量传递方案，并分析了每种情况下所需粒子束线上的必要设备。此外，我们指出，激光驱动的治疗单元可能是放射治疗中运动适应的理想工具。原因是在超短束中具有高粒子数的灵活龙门架和光束的时间结构的潜力。需要解决的一个挑战是在几个光束线元件中产生的二次辐射。
