Tripathi Rudra Deo, Tripathi Preeti, Dwivedi Sanjay, Dubey Sonali, Chatterjee Sandipan, Chakrabarty Debasis, Trivedi Prabodh K
Council of Scientific and Industrial Research-National Botanical Research Institute (CSIR-NBRI) Lucknow, India.
Front Physiol. 2012 Jul 23;3:275. doi: 10.3389/fphys.2012.00275. eCollection 2012.
Arsenic (As) contamination of drinking water and groundwater used for irrigation can lead to contamination of the food chain and poses serious health risk to people worldwide. To reduce As intake through the consumption of contaminated food, identification of the mechanisms for As accumulation and detoxification in plant is a prerequisite to develop efficient phytoremediation methods and safer crops with reduced As levels. Transcriptome, proteome, and metabolome analysis of any organism reflects the total biological activities at any given time which are responsible for the adaptation of the organism to the surrounding environmental conditions. As these approaches are very important in analyzing plant As transport and accumulation, we termed "Arsenomics" as approach which deals transcriptome, proteome, and metabolome alterations during As exposure. Although, various studies have been performed to understand modulation in transcriptome in response to As, many important questions need to be addressed regarding the translated proteins of plants at proteomic and metabolomic level, resulting in various ecophysiological responses. In this review, the comprehensive knowledge generated in this area has been compiled and analyzed. There is a need to strengthen Arsenomics which will lead to build up tools to develop As-free plants for safe consumption.
用于饮用和灌溉的饮用水及地下水中的砷（As）污染会导致食物链污染，并对全球人类健康构成严重风险。为了减少通过食用受污染食物摄入的砷，识别植物中砷积累和解毒的机制是开发有效的植物修复方法以及培育砷含量降低的更安全作物的先决条件。对任何生物体进行转录组、蛋白质组和代谢组分析，都能反映出该生物体在任何给定时间的总体生物活性，这些活性负责生物体对周围环境条件的适应。由于这些方法在分析植物砷转运和积累方面非常重要，我们将“砷组学”定义为研究砷暴露期间转录组、蛋白质组和代谢组变化的方法。尽管已经开展了各种研究来了解转录组对砷的响应调节，但在蛋白质组学和代谢组学水平上，关于植物翻译后的蛋白质仍有许多重要问题需要解决，这些问题会导致各种生态生理反应。在这篇综述中，我们对该领域产生的全面知识进行了汇编和分析。有必要加强砷组学研究，这将有助于建立相关工具，培育出可供安全食用的无砷植物。
