Gupta Digant, Vashi Pankaj G, Trukova Kristen, Lis Christopher G, Lammersfeld Carolyn A
Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL 60099, USA.
Exp Ther Med. 2011 Mar;2(2):181-193. doi: 10.3892/etm.2011.205. Epub 2011 Jan 20.
Vitamin D deficiency has been found to be associated with a variety of cancers, including prostate, multiple myeloma, colorectal and breast cancer. Several studies have shown vitamin D levels to have an inverse relation with cancer mortality, while others have considered it a potential risk factor. Vitamin D is believed to influence cancer prevalence, risk and survival; hence the need to assess vitamin D levels in cancer. Although numerous studies have been conducted to demonstrate vitamin D deficiency as a risk factor for cancer, relatively few have studied its prevalence. Moreover, studies estimating prevalence differ from each other, with respect to study population, sample size, study design, definition of vitamin D deficiency used and method of vitamin D assessment (with most studies limited to one particular type of cancer with relatively small sample sizes). Therefore, we qualitatively reviewed the epidemiological evidence in the oncology literature on the prevalence of vitamin D deficiency and insufficiency as measured by serum vitamin D concentrations.
维生素D缺乏已被发现与多种癌症相关，包括前列腺癌、多发性骨髓瘤、结直肠癌和乳腺癌。多项研究表明维生素D水平与癌症死亡率呈负相关，而其他一些研究则认为它是一个潜在的风险因素。维生素D被认为会影响癌症的患病率、风险和生存率；因此有必要评估癌症患者的维生素D水平。尽管已经进行了大量研究来证明维生素D缺乏是癌症的一个风险因素，但相对较少有研究其患病率。此外，估计患病率的研究在研究人群、样本量、研究设计、所采用的维生素D缺乏定义以及维生素D评估方法方面各不相同（大多数研究仅限于一种特定类型的癌症且样本量相对较小）。因此，我们对肿瘤学文献中关于血清维生素D浓度所衡量的维生素D缺乏和不足患病率的流行病学证据进行了定性综述。
