European Bioinformatics Institute, Hinxton, Cambridge, UK Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, the Netherlands The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge, UK.
J Thromb Haemost. 2012 Nov;10(11):2399-402. doi: 10.1111/j.1538-7836.2012.04930.x.
The platelet field is undergoing a radical transformation from reductionist simplification to large scale integration. Following the era of simplification whereby biological processes were dissected at the molecular and atomic level, new technologies have now generated an overwhelming flow of information that can only be comprehended in an integrated approach. High throughput analyses of transcription and translation in megakaryocytes and platelets, individual analyses of membranes and secretory granules, the clustering of pathways for platelet activation and inhibition in signalosomes all add to a complexity that requires platforms for knowledge accumulation. Here we introduce Reactome, a curated knowledgebase of biological pathways with extensive coverage of pathways relevant to megakaryocytes, platelets and haemostasis. This resource is compared with other data resources for platelets, e.g. the Platelet Web.
血小板领域正在经历从简化还原论到大规模集成的根本转变。继生物学过程在分子和原子水平上被剖析的简化时代之后，新技术现在产生了压倒性的信息流，只能以集成的方式理解。对巨核细胞和血小板中的转录和翻译进行高通量分析，对膜和分泌颗粒进行单独分析，血小板激活和抑制信号转导途径的聚类都增加了需要知识积累平台的复杂性。在这里，我们介绍 Reactome，这是一个经过精心整理的生物途径知识库，涵盖了与巨核细胞、血小板和止血相关的广泛途径。该资源与其他血小板相关的数据资源进行了比较，例如血小板网络（Platelet Web）。
