Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University of Regensburg, Regensburg, Germany.
Radiat Oncol. 2012 Sep 24;7:162. doi: 10.1186/1748-717X-7-162.
Radiation therapy is an established modality in the treatment of head and neck cancer patients. Compromised wound healing in irradiated tissues is a common and challenging clinical problem. The pathophysiology and underlying cellular mechanisms including the complex interaction of cytokines and growth factors are still not understood completely. In this review, the current state of research regarding the pathomechanisms of compromised wound healing in irradiated tissues is presented. Current and possible future treatment strategies are critically reviewed.
放射治疗是治疗头颈部癌症患者的一种既定方式。在接受放射治疗的组织中，伤口愈合受损是一个常见且具有挑战性的临床问题。其病理生理学和潜在的细胞机制，包括细胞因子和生长因子的复杂相互作用，仍不完全清楚。在这篇综述中，介绍了目前关于放射治疗组织中伤口愈合受损的病理机制的研究现状。对当前和未来可能的治疗策略进行了批判性评价。
