Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
PLoS One. 2012;7(9):e45048. doi: 10.1371/journal.pone.0045048. Epub 2012 Sep 19.
Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake.
类黄酮因其对健康的影响而引起了相当大的关注。8- prenylnaringenin（8-PN）存在于常见的啤酒花（Humulus lupulus）中，被认为是啤酒消费对健康产生影响的原因。我们希望通过在小鼠去神经模型中比较 8-PN 与完整柚皮素在预防废用性肌肉萎缩方面的作用，阐明prenylation 对膳食类黄酮生理功能的影响。8-PN（而非柚皮素）的摄入可防止腓肠肌重量减轻，进一步支持了参与肌肉萎缩的关键泛素连接酶atrogin-1的蛋白含量没有诱导，以及 Akt 磷酸化的激活。腓肠肌中 8-PN 的含量比柚皮素高十倍。这些结果表明，与柚皮素相比，8-PN 更有效地集中到骨骼肌中，从而对废用性肌肉萎缩发挥预防作用。prenylation 通过增强其通过饮食摄入进入肌肉组织的积累，可能为 8-PN 产生新的功能。
