Giardiello F M, Hansen F C, Lazenby A J, Hellman D B, Milligan F D, Bayless T M, Yardley J H
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dig Dis Sci. 1990 Feb;35(2):257-60. doi: 10.1007/BF01536772.
Collagenous colitis is a clinicopathologic syndrome characterized by chronic watery diarrhea and a mucosal inflammatory process with increased subepithelial collagen band on colonic biopsy. This disorder occurs primarily in females, and the etiology is unknown. We report the atypical presentation of collagenous colitis in two older-aged men following prolonged use of nonsteroidal antiinflammatory agents and short-term use of antibiotics. Although one patient had colonic pseudomembranes, neither patient had microbiological evidence of C. difficile toxin or infection. A variety of medications were initially given to these patients without resolution of diarrhea. Only after the diagnosis of collagenous colitis was made and antiinflammatory drugs directed at the colitis given did the diarrhea abate. These cases illustrate an unusual presentation of collagenous colitis with possible implications for pathogenesis.
胶原性结肠炎是一种临床病理综合征，其特征为慢性水样腹泻以及结肠活检显示上皮下胶原带增厚的黏膜炎症过程。这种疾病主要发生在女性，病因不明。我们报告了两名老年男性在长期使用非甾体抗炎药和短期使用抗生素后出现的胶原性结肠炎非典型表现。尽管一名患者有结肠假膜，但两名患者均无艰难梭菌毒素或感染的微生物学证据。最初给这些患者使用了多种药物，但腹泻未缓解。仅在诊断为胶原性结肠炎并给予针对结肠炎的抗炎药物后，腹泻才减轻。这些病例说明了胶原性结肠炎的一种不寻常表现及其对发病机制可能产生的影响。
