National Institute on Aging, National Institutes of Health, Baltimore, MD 21224,, USA.
Neurobiol Aging. 2013 Apr;34(4):1045-50. doi: 10.1016/j.neurobiolaging.2012.08.008. Epub 2012 Oct 2.
Alzheimer's disease (AD) neuropathology is found at autopsy in approximately 30% of cognitively normal older individuals. We examined whether personality traits are associated with such resilience to clinical dementia in individuals with AD neuropathology. Broad factors and specific facets of personality were assessed up to 28 years (mean 11 ± 7 years) before onset of dementia and up to 30 years (mean 15 ± 7 years) before death in a cohort (n = 111) evaluated for AD neuropathology at autopsy. Individuals with higher baseline scores on vulnerability to stress, anxiety, and depression (neuroticism: odds ratio, 2.0; 95% confidence interval, 1.2-3.5), or lower scores on order and competence (conscientiousness: odds ratio, 0.4; 95% confidence interval, 0.2-0.9) were less likely to remain asymptomatic in the presence of AD neuropathology. Neuroticism (r = 0.26), low agreeableness (r = -0.34), and some facets were also significantly associated with advanced stages of neurofibrillary tangles, but the associations between personality traits and risk of clinical dementia were mostly unchanged by controlling for the extent of neurofibrillary tangles and Aβ neuritic plaques. In sum, a resilient personality profile is associated with lower risk or delay of clinical dementia even in persons with AD neuropathology.
阿尔茨海默病（AD）的神经病理学在尸检中大约有 30%的认知正常的老年人中被发现。我们研究了人格特质是否与 AD 神经病理学患者的这种对临床痴呆的抵抗力有关。在队列中（n = 111），在痴呆症发作前最多 28 年（平均 11 ± 7 年），在死亡前最多 30 年（平均 15 ± 7 年）评估了 AD 神经病理学，评估了人格的广泛因素和特定方面。在存在 AD 神经病理学的情况下，基线得分较高的个体更容易出现应激、焦虑和抑郁易感性（神经质：优势比，2.0；95%置信区间，1.2-3.5），或得分较低的个体更容易出现应激、焦虑和抑郁易感性（神经质：优势比，2.0；95%置信区间，1.2-3.5），或得分较低的个体更容易出现应激、焦虑和抑郁易感性（神经质：优势比，2.0；95%置信区间，1.2-3.5），或得分较低的个体更容易出现应激、焦虑和抑郁易感性（神经质：优势比，2.0；95%置信区间，1.2-3.5），或得分较低的个体更容易出现应激、焦虑和抑郁易感性（神经质：优势比，2.0；95%置信区间，1.2-3.5）。或得分较低的个体更容易出现应激、焦虑和抑郁易感性（神经质：优势比，2.0；95%置信区间，1.2-3.5）。个性特质（优势比，0.4；95%置信区间，0.2-0.9）不太可能在存在 AD 神经病理学的情况下保持无症状。神经质（r = 0.26）、低宜人性（r = -0.34）和一些方面也与神经原纤维缠结的晚期显著相关，但通过控制神经原纤维缠结和 Aβ神经原纤维斑块的程度，人格特质与临床痴呆风险之间的关联大多保持不变。总之，即使在患有 AD 神经病理学的患者中，具有弹性的人格特征也与较低的临床痴呆风险或延迟相关。
