Chanda Arijit, Kwon Jeff S, Wolff Armand John, Manthous Constantine A
Section of Pulmonary, Critical Care, and Sleep Medicine, Bridgeport Hospital, Bridgeport, CT 06610, USA.
Pulm Med. 2012;2012:568690. doi: 10.1155/2012/568690. Epub 2012 Oct 11.
Obesity is increasing world-wide; obesity hypoventilation syndrome (OHS), formerly Pickwickian syndrome, has increased in parallel. Despite its prevalence, OHS has not been studied well, but there is abundant evidence that it is tightly linked with sleep-disordered breathing, most commonly obstructive sleep apnea. This article reviews the pathophysiology of OHS as well as the literature regarding the benefits of treating this disorder with positive airway pressure. We also emphasize that while positive pressure treatments may temporize cardiopulmonary disease progression, simultaneous pursuit of weight reduction is central to long-term management of this condition.
肥胖在全球范围内呈上升趋势；肥胖低通气综合征（OHS），即以前的匹克威克综合征，也随之增加。尽管其发病率很高，但对OHS的研究并不充分，但有大量证据表明它与睡眠呼吸障碍密切相关，最常见的是阻塞性睡眠呼吸暂停。本文回顾了OHS的病理生理学以及关于使用气道正压治疗该疾病的益处的文献。我们还强调，虽然正压治疗可能会暂时延缓心肺疾病的进展，但同时追求体重减轻是这种疾病长期管理的核心。
