Denz H, Fuchs D, Hausen A, Huber H, Nachbaur D, Reibnegger G, Thaler J, Werner E R, Wachter H
Universitätsklinik für Innere Medizin, Universität Innsbruck.
Klin Wochenschr. 1990 Feb 15;68(4):218-22. doi: 10.1007/BF01662720.
Neopterin is released by stimulated macrophages. In this study we analyzed the diagnostic potential of urinary neopterin concentrations in patients with bacterial and viral infection. All but one of 17 patients with viral infection had increased urinary neopterin concentrations. Patients with bacterial urinary tract infection also showed increased neopterin concentrations, whereas patients with bacterial pneumonia had significantly lower neopterin levels. In addition, patients with acute bacterial pneumonia had lower neopterin levels than patients with protracted infection. A significant inverse correlation between urinary neopterin and hemoglobin concentrations was found. Neopterin concentrations could serve as a helpful additional marker of infectious diseases. Combined with other clinical and laboratory parameters it is a useful parameter for distinguishing between viral and bacterial origins of infection, as was shown by multivariate stepwise linear discriminant analysis.
新蝶呤由受刺激的巨噬细胞释放。在本研究中，我们分析了细菌和病毒感染患者尿中新蝶呤浓度的诊断潜力。17例病毒感染患者中，除1例之外，其余患者的尿新蝶呤浓度均升高。细菌性尿路感染患者的新蝶呤浓度也升高，而细菌性肺炎患者的新蝶呤水平显著较低。此外，急性细菌性肺炎患者的新蝶呤水平低于迁延性感染患者。发现尿新蝶呤与血红蛋白浓度之间存在显著的负相关。新蝶呤浓度可作为传染病的一个有用的附加标志物。多变量逐步线性判别分析表明，结合其他临床和实验室参数，它是区分感染的病毒和细菌来源的一个有用参数。
