Lu Hong, Gargesha Madhusudhana, Wang Zhao, Chamie Daniel, Attizzani Guilherme F, Kanaya Tomoaki, Ray Soumya, Costa Marco A, Rollins Andrew M, Bezerra Hiram G, Wilson David L
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Biomed Opt Express. 2012 Nov 1;3(11):2809-24. doi: 10.1364/BOE.3.002809. Epub 2012 Oct 15.
Intravascular optical coherence tomography (iOCT) is being used to assess viability of new coronary artery stent designs. We developed a highly automated method for detecting stent struts and measuring tissue coverage. We trained a bagged decision trees classifier to classify candidate struts using features extracted from the images. With 12 best features identified by forward selection, recall (precision) were 90%-94% (85%-90%). Including struts deemed insufficiently bright for manual analysis, precision improved to 94%. Strut detection statistics approached variability of manual analysis. Differences between manual and automatic area measurements were 0.12 ± 0.20 mm(2) and 0.11 ± 0.20 mm(2) for stent and tissue areas, respectively. With proposed algorithms, analyst time per stent should significantly reduce from the 6-16 hours now required.
血管内光学相干断层扫描(iOCT)正被用于评估新型冠状动脉支架设计的可行性。我们开发了一种高度自动化的方法来检测支架支柱并测量组织覆盖情况。我们训练了一个袋装决策树分类器,使用从图像中提取的特征对候选支柱进行分类。通过前向选择确定了12个最佳特征,召回率(精确率)为90%-94%(85%-90%)。包括那些对于人工分析来说亮度不够的支柱,精确率提高到了94%。支柱检测统计数据接近人工分析的变异性。人工测量和自动测量的支架面积和组织面积差异分别为0.12±0.20平方毫米和0.11±0.20平方毫米。使用所提出的算法,每个支架的分析时间应从目前所需的6-16小时显著减少。