Jacquemier J D, Hassoun J, Torrente M, Martin P M
Institut J. Paoli, I. Calmettes, Marseille, France.
Breast Cancer Res Treat. 1990 Feb;15(2):109-17. doi: 10.1007/BF01810783.
The purpose of this study was to determine the distribution of ER+ (estrogen receptor) and PR+ (progesterone receptor) epithelial cells in normal mammary tissue or in tissue in contact with or involved in benign or malignant processes. Three important findings emerged from this study. First, a true dissociation was observed between ER+ and PR+ cells in mammary tissue. In premenopausal women some cells express only progesterone receptors. In premenopausal normal tissue, regardless of the menstrual cycle status, 6% of cells are ER+ and 29% PR+. Second, during the menstrual cycle the percentage of positive cells varies. This finding would indicate a change in cell recruitment rather than in intracellular levels. Finally, specific changes in the proportion of positive cells in normal tissue in contact with epithelial proliferations were noted. This finding suggests the possibility of either a diffusible factor or a cellular pathological process spreading beyond areas displaying morphological changes.
本研究的目的是确定雌激素受体（ER+）和孕激素受体（PR+）上皮细胞在正常乳腺组织、或与良性或恶性病变相关或受其累及的组织中的分布情况。该研究有三项重要发现。首先，在乳腺组织中观察到ER+和PR+细胞之间存在真正的分离。在绝经前女性中，一些细胞仅表达孕激素受体。在绝经前正常组织中，无论月经周期状态如何，6%的细胞为ER+，29%为PR+。其次，在月经周期中，阳性细胞的百分比会发生变化。这一发现表明是细胞募集发生了变化，而非细胞内水平改变。最后，观察到与上皮增生相关的正常组织中阳性细胞比例有特定变化。这一发现提示，可能存在一种可扩散因子，或者一种细胞病理过程，其扩散范围超出了显示形态学变化的区域。
