Toll 样受体对细菌毒力策略的影响。
The impact of Toll-like receptors on bacterial virulence strategies.
机构信息
Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Curr Opin Microbiol. 2013 Feb;16(1):17-22. doi: 10.1016/j.mib.2012.11.004. Epub 2013 Jan 3.
Abstract
The mammalian immune system has evolved in the presence of microbes, both pathogenic and commensal. The consequences of microbial recognition by the host has led to the development of compensatory mechanisms by both the host and microbe to either resist or tolerate the existence of the other. In this review we discuss examples of this co-evolutionary relationship. Because of space considerations and for conceptual clarity, we have focused on detection of bacteria by the Toll-like receptor (TLR) family and highlight examples of bacterial strategies to evade, subvert and in some cases even utilize these receptors.
摘要
哺乳动物的免疫系统是在存在微生物（包括病原体和共生体）的情况下进化而来的。宿主对微生物的识别所带来的后果，促使宿主和微生物都发展出了补偿机制，以抵抗或耐受对方的存在。在这篇综述中，我们讨论了这种共同进化关系的例子。由于篇幅限制和概念清晰的考虑，我们专注于 Toll 样受体（TLR）家族对细菌的检测，并强调了细菌逃避、颠覆甚至在某些情况下利用这些受体的策略的例子。
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