Meng Ellis, Hoang Tuan
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089-1111, USA.
Ther Deliv. 2012 Dec;3(12):1457-67. doi: 10.4155/tde.12.132.
Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics. Recent advances in drug administration technologies are discussed and remaining challenges are highlighted.
可植入给药系统提供了新的方法，以便在整个治疗期间实现治疗药物浓度，从而优化药物作用。本文重点关注通过微纳制造技术和微流体技术实现的可植入给药系统所达成的新型给药方式。文中讨论了给药技术的最新进展，并强调了尚存的挑战。
