Beikert F C, Schönfeld B S, Frank U, Augustin M
IVDP - Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
Hautarzt. 2013 Jan;64(1):40-6. doi: 10.1007/s00105-012-2505-x.
Phytotherapeutics are widely used in medicine. The aim of this study was the evaluation of the antiinflammatory potential of seven medical plant extracts using the ultraviolet- (UV)-erythema test.
Randomized, placebo-controlled study on 40 healthy subjects. Test areas on the upper back were irradiated with the 1.5 fold UV-B minimal erythema dose (MED). Formulations of Aloe vera, Chamomilla recutita, Hamamelis virginiana, Melissa officinalis, Mentha arvensis, Melaleuca alternifolia, Coriandrum sativum as well as 1% hydrocortisone acetate and 0.1% betamethasone valerate as positive controls and unguentum leniens as vehicle control were applied under occlusion on the irradiated areas and on non-irradiated area on the contralateral side. Photometric assessment of the erythema was performed before the application of the substances (t0), at 24 h (t1) and at 48 h (t2).
Aloe vera, Chamomilla recutita, Melissa officinalis, Melaleuca alternifolia and Coriandrum sativum showed an antiinflammatory effect compared to UV-control and unguentum leniens. However, the results were only statistically significant for Aloe vera. All tested plant extracts were well tolerated.
Aloe vera possesses an antiinflammatory effect on UV-induced erythemas.
植物疗法在医学中广泛应用。本研究旨在通过紫外线（UV）红斑试验评估七种药用植物提取物的抗炎潜力。
对40名健康受试者进行随机、安慰剂对照研究。上背部的测试区域用1.5倍UV-B最小红斑量（MED）进行照射。将芦荟、洋甘菊、北美金缕梅、蜜蜂花、薄荷、互叶白千层、芫荽的制剂以及作为阳性对照的1%醋酸氢化可的松和0.1%戊酸倍他米松，以及作为赋形剂对照的温和软膏，在封闭条件下涂抹于照射区域和对侧未照射区域。在涂抹物质前（t0）、24小时（t1）和48小时（t2）对红斑进行光度评估。
与紫外线对照和温和软膏相比，芦荟、洋甘菊、蜜蜂花、互叶白千层和芫荽显示出抗炎作用。然而，结果仅对芦荟具有统计学意义。所有测试的植物提取物耐受性良好。
芦荟对紫外线诱导的红斑具有抗炎作用。
