Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931-1295, USA.
J Mater Sci Mater Med. 2013 Apr;24(4):1093-104. doi: 10.1007/s10856-013-4854-0. Epub 2013 Jan 26.
Magnetoelastic (ME) biomaterials are ferromagnetic materials that physically deform when exposed to a magnetic field. This work describes the real-time control and monitoring capabilities of ME biomaterials in wound healing. Studies were conducted to demonstrate the capacity of the materials to monitor changes in protein adsorption and matrix stiffness. In vitro experiments demonstrated that ME biomaterials can monitor cell adhesion and growth in real-time, and a long-term in vivo study demonstrated their ability to monitor the host response (wound healing) to an implant and control local cell density and collagen matrix production at the soft tissue-implant interface. This approach represents a potentially self-aware and post-deployment activated biomaterial coating as a means to monitor an implant surface and provide an adjuvant therapy for implant fibrosis.
磁弹（ME）生物材料是指在磁场作用下会发生物理变形的铁磁材料。本工作描述了 ME 生物材料在伤口愈合中的实时控制和监测功能。研究旨在证明材料监测蛋白吸附和基质硬度变化的能力。体外实验表明，ME 生物材料可以实时监测细胞黏附和生长，长期体内研究表明其能够监测宿主对植入物的反应（伤口愈合），并控制软组织-植入物界面处的局部细胞密度和胶原基质产生。这种方法代表了一种潜在的自感知和部署后激活的生物材料涂层，可用于监测植入物表面并为植入物纤维化提供辅助治疗。
