Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Biotechnol Adv. 2013 Jul-Aug;31(4):438-49. doi: 10.1016/j.biotechadv.2013.01.006. Epub 2013 Jan 26.
Tuberculosis (TB) remains one of the most devastating infectious diseases and its eradication is still unattainable given the limitations of current technologies for diagnosis, treatment and prevention. The World Health Organization's goal to eliminate TB globally by 2050 remains an ongoing challenge as delayed diagnosis and misdiagnosis of TB continue to fuel the worldwide epidemic. Despite considerable improvements in diagnostics for the last few decades, a simple and effective point-of-care TB diagnostic test is yet not available. Here, we review the current assays used for TB diagnosis, and highlight the recent advances in nanotechnology and microfluidics that potentially enable new approaches for TB diagnosis in resource-constrained settings.
结核病（TB）仍然是最具破坏性的传染病之一，由于当前诊断、治疗和预防技术的局限性，其消除仍然遥不可及。世界卫生组织到 2050 年在全球消除结核病的目标仍然是一个持续存在的挑战，因为结核病的诊断延迟和误诊仍在助长全球疫情。尽管在过去几十年中诊断技术有了相当大的改进，但仍然没有简单有效的即时护理结核病诊断测试。在这里，我们回顾了目前用于结核病诊断的检测方法，并强调了纳米技术和微流控技术的最新进展，这些技术可能为资源有限的环境中的结核病诊断提供新方法。
