Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Chem Commun (Camb). 2013 Apr 11;49(28):2873-5. doi: 10.1039/c3cc40472b.
Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.
通过开环复分解聚合（ROMP）制备了降冰片烯基修饰的肽基酶底物的聚合物。在水溶性均聚物上展示的肽保留了被与疾病相关的酶进行酶促处理的能力。相比之下，当肽在源自自组装两亲嵌段共聚物的纳米颗粒上密集排列时，它们作为酶底物的活性降低。
