终丝钙焦磷酸盐二水化合物沉积病。
Calcium pyrophosphate dihydrate deposition disease of the filum terminale.
机构信息
Department of Neurosurgery, San Filippo Neri Hospital, Rome, Italy.
出版信息
Eur Spine J. 2013 May;22 Suppl 3(Suppl 3):S501-5. doi: 10.1007/s00586-013-2723-7. Epub 2013 Mar 2.
INTRODUCTION
Calcium pyrophosphate dihydrate crystal deposition disease (CPPDD) is a rare benign inflammatory joint disorder characterized by the presence of calcium pyrophosphate dihydrate crystal in the interarticular and periarticular tissue. It has been rarely described with spinal localization.
METHODS
A 50-year-old woman, affected by CPPDD, presented a progressive weakness of both lower limbs associated with neurogenic claudication. Neuroradiological examinations revealed the presence of two intradural calcified lesions at level L3-L4, with no post-contrast enhancement.
RESULTS
Surgery was performed and the histopathological exams documented the presence of rod-shaped crystals embedded in a fibrocartilaginous stroma. The postoperative course was uneventful and the patient experienced complete symptoms relief with a 5-year follow-up.
CONCLUSION
Intradural CPPD localization at the filum terminale is an extremely rare occurrence. Total removal should be preferably attempted with a long-term focal control of the disease as we observed in our case.
简介
焦磷酸钙二水合物晶体沉积病（CPPDD）是一种罕见的良性炎症性关节疾病，其特征是关节内和关节周围组织中存在焦磷酸钙二水合物晶体。它在脊柱定位中很少被描述。
方法
一名 50 岁女性患有 CPPDD，表现为双侧下肢进行性无力，伴有神经性跛行。神经放射学检查显示 L3-L4 水平存在两个硬膜内钙化病变，无对比增强。
结果
手术进行，组织病理学检查证实存在嵌入纤维软骨基质中的杆状晶体。术后过程顺利，患者在 5 年随访中完全缓解症状。
结论
终丝内硬膜 CPPD 定位极为罕见。我们在病例中观察到，最好尝试通过长期的疾病局部控制来进行完全切除。
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