Cerný S, Mráz J, Flek J, Tichý M
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
Int Arch Occup Environ Health. 1990;62(3):243-7. doi: 10.1007/BF00379441.
Administration of ethanol in several doses during human exposure to styrene can inhibit the urinary mandelic and phenylglyoxylic acid excretion in a way similar to that reported when ethanol was administered as a single dose. Sensitivity to this inhibitory effect has been found to differ with individual subjects. Differences in long-term consumption of ethanol resulting in different induction of the oxidizing enzymes are suggested to account for this finding. Intra-individual variation in the influence of acute ethanol ingestion on the excretion rate of the mentioned acids can also occur. The habit of drinking ethanol might be important, even for partial redirection of the styrene metabolism from styrene glycol oxidation to styrene glycol conjugation with beta-glucuronic acid and/or sulfate. The consequences of these observations for the occupational hygiene practice are briefly outlined.
人体接触苯乙烯期间多次给予乙醇，可抑制尿中扁桃酸和苯乙醇酸的排泄，其方式与单次给予乙醇时的报道相似。已发现个体对这种抑制作用的敏感性存在差异。长期饮用乙醇导致氧化酶诱导程度不同，这一差异被认为是造成该结果的原因。急性摄入乙醇对上述酸排泄率的影响也可能存在个体内差异。即使对于将苯乙烯代谢从苯乙烯二醇氧化部分重定向为苯乙烯二醇与β-葡萄糖醛酸和/或硫酸盐结合而言，饮酒习惯可能也很重要。简要概述了这些观察结果对职业卫生实践的影响。
