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使用傅里叶域光学相干断层扫描技术评估供体角膜前基质混浊情况。

Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas.

作者信息

Bald Matthew R, Stoeger Christopher, Galloway Joshua, Tang Maolong, Holiman Jeffrey, Huang David

机构信息

Center for Ophthalmic Optics & Lasers, Casey Eye Institute and Department of Ophthalmology, Oregon Health & Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239-4197, USA.

出版信息

J Ophthalmol. 2013;2013:397680. doi: 10.1155/2013/397680. Epub 2013 Mar 28.

DOI:10.1155/2013/397680
PMID:23606944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3625538/
Abstract

Purpose. To evaluate Fourier-domain optical coherence tomography (FD-OCT) as an adjunct to traditional slit lamp examination of donor corneas with suspected Anterior Stromal Opacities. Methods. Seven corneas suspected of having anterior stromal opacities by slit lamp examination were evaluated with FD-OCT. Each cornea was evaluated to confirm the presence of opacity and, if present, the depth of opacity was measured. Results. The opacity depth ranged from 82  μ m to 624  μ m. The initial slit lamp impressions of five of the seven corneas were confirmed by OCT. In two corneas, the OCT findings were different from the initial slit lamp impressions. Slit lamp examination of the first cornea gave the impression of anterior stromal scarring, but OCT showed that the opacity was limited to the epithelium. Slit lamp examination of the second cornea suggested opacity limited to the epithelium, but OCT identified significant sub-Bowman's scarring. In all cases, the Eye Bank Technicians reported that the location and depth of corneal opacity were more sharply defined by OCT than by slit lamp. Conclusion. The high resolution of OCT makes it easier to determine the location of corneal opacities compared to slit lamp examinations. This enhanced visualization can improve decisions regarding transplant suitability of donor corneas.

摘要

目的。评估傅里叶域光学相干断层扫描（FD - OCT）作为对疑似前基质混浊的供体角膜进行传统裂隙灯检查的辅助手段。方法。对7只经裂隙灯检查怀疑有前基质混浊的角膜进行FD - OCT评估。对每只角膜进行评估以确认混浊的存在，若存在混浊，则测量其深度。结果。混浊深度范围为82μm至624μm。7只角膜中有5只角膜的初始裂隙灯检查印象经OCT证实。在2只角膜中，OCT检查结果与初始裂隙灯检查印象不同。对第一只角膜的裂隙灯检查显示为前基质瘢痕形成，但OCT显示混浊仅限于上皮层。对第二只角膜的裂隙灯检查提示混浊仅限于上皮层，但OCT发现Bowman层下有明显瘢痕形成。在所有病例中，眼库技术人员报告称，与裂隙灯相比，OCT能更清晰地确定角膜混浊的位置和深度。结论。与裂隙灯检查相比，OCT的高分辨率使其更容易确定角膜混浊的位置。这种增强的可视化可以改善关于供体角膜移植适用性的决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/478e0be64f1f/JOP2013-397680.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/41b70054c5fd/JOP2013-397680.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/98be57c817c5/JOP2013-397680.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/e844ab9d1e0f/JOP2013-397680.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/478e0be64f1f/JOP2013-397680.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/41b70054c5fd/JOP2013-397680.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/98be57c817c5/JOP2013-397680.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/e844ab9d1e0f/JOP2013-397680.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb4/3625538/478e0be64f1f/JOP2013-397680.004.jpg

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