Verdina Tommaso, Giacomelli Giovanni, Sodi Andrea, Pennino Monica, Paggini Chiara, Murro Vittoria, Virgili Gianni, Menchini Ugo
Department of Specialized Surgical Sciences, Eye Clinic, University of Florence, Largo Brambilla 3, Florence, Italy.
Eur J Ophthalmol. 2013 Sep-Oct;23(5):723-31. doi: 10.5301/ejo.5000291. Epub 2013 Apr 29.
To evaluate the efficacy of biofeedback (BF) microperimetric rehabilitation in patients with Stargardt disease (STGD).
Eighteen patients with STGD with unstable fixation located in the superior retina and best-corrected visual acuity (BCVA) between 20/100 and 20/320 in the better eye were recruited. All the patients underwent Nidek MP-1 microperimetry and fixation analysis. Twelve patients underwent 8 consecutive BF training sessions of 10 minutes each, performed once a week in the better eye. Six patients did not receive any training and were used as controls. In both groups, BCVA, reading speed, contrast sensitivity, bivariate contour ellipse area (BCEA), and retinal sensitivity were evaluated in the better eye at baseline and after 10 weeks. Paired and unpaired t tests were used as appropriate.
In the control group, after the follow-up period, fixation pattern did not show any modification and the other parameters worsened or remained unchanged. On the contrary, the BF group showed significantly improved stabilization of fixation (mean BCEA 68.2% from 5.63°2 to 1.58°2), improved mean BCVA (from 34.00 to 37.67 letters), higher mean reading speed (from 66.67 to 84.00 words/min), higher contrast sensitivity (from 16.33 to 18.75 letters), and improved retinal sensitivity (from 10.68 to 12.29 dB). The comparison of the results obtained in the 2 groups was statistically significant for all the considered parameters except for retinal sensitivity.
Biofeedback rehabilitation with the MP-1 increases quality of vision in patients with STGD, leading to a stabilization of fixation and a consequent improvement of patients’ visual function and reading abilities
评估生物反馈（BF）微视野康复对斯塔加特病（STGD）患者的疗效。
招募了18例STGD患者，其上方视网膜注视不稳定，较好眼的最佳矫正视力（BCVA）在20/100至20/320之间。所有患者均接受了尼德克MP-1微视野检查和注视分析。12例患者在较好眼进行了连续8次每次10分钟的BF训练，每周进行一次。6例患者未接受任何训练，作为对照组。两组患者在基线时以及10周后均对较好眼的BCVA、阅读速度、对比敏感度、双变量轮廓椭圆面积（BCEA）和视网膜敏感度进行了评估。适当使用配对和非配对t检验。
在对照组中，随访期后，注视模式未显示任何改变，其他参数恶化或保持不变。相反，BF组的注视稳定性显著提高（平均BCEA从5.63°2降至1.58°2，降幅为68.2%），平均BCVA提高（从34.00提高到37.67个字母），平均阅读速度更高（从66.67提高到84.00单词/分钟），对比敏感度更高（从16.33提高到18.75个字母），视网膜敏感度提高（从10.68提高到12.29 dB）。除视网膜敏感度外，两组所得结果在所有考虑的参数上的比较均具有统计学意义。
使用MP-1进行生物反馈康复可提高STGD患者的视力质量，使注视稳定，从而改善患者的视觉功能和阅读能力。
