Zhang Ning, Wu Yong-Ping, Qian Sheng-Jun, Teng Chong, Chen Shuai, Li Hang
Department of Orthopaedics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China.
ScientificWorldJournal. 2013 Apr 4;2013:134582. doi: 10.1155/2013/134582. Print 2013.
Platelet-rich plasma (PRP) therapy is a recently developed technique that uses a concentrated portion of autologous blood to try to improve and accelerate the healing of various tissues. There is a considerable interest in using these PRP products for the treatment used in bone deficiency healing. Because PRP products are safe and easy to prepare and administer, there has been increased attention toward using PRP in numerous clinical settings. The benefits of PRP therapy appear to be promising, and many investigators are exploring the ways in which this therapy can be used in the clinical setting. At present, the molecular mechanisms of bone defect repair studies have focused on three aspects of the inflammatory cytokines, growth factors and angiogenic factors. The role of PRP works mainly through these three aspects of bone repair. The purpose of this paper is to review the current evidence on the mechanism of the effect of PRP in bone deficiency healing.
富血小板血浆（PRP）疗法是一种最近开发的技术，它使用自体血液的浓缩部分来试图改善和加速各种组织的愈合。人们对使用这些PRP产品治疗骨缺损愈合有相当大的兴趣。由于PRP产品安全且易于制备和给药，因此在众多临床环境中使用PRP受到了越来越多的关注。PRP疗法的益处似乎很有前景，许多研究人员正在探索这种疗法在临床环境中的使用方式。目前，骨缺损修复研究的分子机制主要集中在炎症细胞因子、生长因子和血管生成因子三个方面。PRP的作用主要通过骨修复的这三个方面来实现。本文的目的是综述目前关于PRP在骨缺损愈合中作用机制的证据。
