Somasundaram Padmini, Vimala N, Mandke Lalita Gauri
Department of Conservative Dentistry and Endodontics, Padmashree Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, India.
J Conserv Dent. 2013 Mar;16(2):152-6. doi: 10.4103/0972-0707.108199.
Dental caries remains the most common dental disease facing mankind. Prevention of initiation and interruption in progression of early lesions are the desirable modes of caries management. There is a scope for agents, which may be used to enhance anti - caries activity. This need has redirected research to develop novel preventive agents that can act as an adjunct to fluoride or independent of it. Casein Phosphopeptide - Amorphous Calcium Phosphate (CPP-ACP) is one such agent that has been proposed to have anti cariogenic properties.
The purpose of this in vitro study was to evaluate the effect of paste containing CPP-ACP, MI Paste, on enamel remineralization.
This study consisted of 30 samples embedded in orthodontic resin with either the buccal or lingual surface exposed. The samples were assigned to either a CPP-ACP containing paste; Fluoridated toothpaste; or a control group. The groups were then subjected to cycling in a demineralizing solution and a remineralizing solution. Groups II and III received prior application of MI paste and Fluoridated toothpaste respectively followed by cycling in a demineralizing solution and a remineralizing solution. Following 14 days of cycling, the samples were sectioned and examined using confocal microscopy. The lesion depth, were evaluated.
Image Proplus software was used to analyze the images. The values were statistically evaluated using one - way ANOVA and Scheffe's Test.
Within the limitations of the study it was concluded that enamel surfaces treated with the CPP-ACP paste exhibited the least lesion depths followed by the enamel surfaces treated with the fluoridated tooth paste and control group respectively.
龋齿仍然是人类面临的最常见的牙科疾病。预防早期病变的发生和阻止其进展是理想的龋齿管理模式。存在可用于增强防龋活性的药物的空间。这种需求促使研究转向开发可作为氟化物辅助剂或独立于氟化物发挥作用的新型预防剂。酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）就是这样一种被认为具有防龋特性的药物。
本体外研究的目的是评估含CPP - ACP的糊剂（MI糊剂）对牙釉质再矿化的影响。
本研究包括30个嵌入正畸树脂的样本，颊面或舌面暴露。样本被分为含CPP - ACP的糊剂组；含氟牙膏组；或对照组。然后将这些组置于脱矿溶液和再矿化溶液中循环处理。第二组和第三组分别先使用MI糊剂和含氟牙膏，然后再置于脱矿溶液和再矿化溶液中循环处理。循环14天后，将样本切片并使用共聚焦显微镜检查。评估病变深度。
使用Image Proplus软件分析图像。使用单因素方差分析和谢费检验对数值进行统计学评估。
在本研究的局限性范围内，得出的结论是，用CPP - ACP糊剂处理的牙釉质表面病变深度最小，其次是分别用含氟牙膏处理的牙釉质表面和对照组。
