Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine, Gwangju 500-757, Korea.
J Ginseng Res. 2011 Jun;35(2):250-5. doi: 10.5142/jgr.2011.35.2.250.
Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 mg/kg body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.
多囊卵巢综合征（PCOS）是育龄妇女中非常常见的内分泌疾病。神经生长因子（NGF）可能参与了 PCOS 的发病机制。在这项研究中，我们研究了高丽红参提取物（KRGE）对己烯雌酚（EV）诱导的大鼠模型中卵巢形态和 NGF 表达的影响。通过向成年周期性大鼠的肌肉内单次注射己烯雌酚（4mg，溶解在芝麻油中）来诱导多囊卵巢。在诱导后 60 天开始，每天口服 KRGE（200mg/kg 体重/天）60 天。EV+KRGE 组的卵巢形态几乎正常化，NGF 也正常化。KRGE 降低了多囊卵巢中大量的窦卵泡数量，并增加了黄体数量。这些结果表明 KRGE 对 PCOS 的治疗具有有益作用。
